SML0448

URB937

≥95% (HPLC)

• Sinônimo(s): Cyclohexylcarbamic acid 3′–carbamoyl–6–hydroxybiphenyl–3–yl ester
• Fórmula empírica (Notação de Hill): C₂₀H₂₂N₂O₄
• Número CAS: 1357160-72-5
• Peso molecular: 354.40
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥95% (HPLC)
• forma: powder (1:1 ratio of product to ethanol)
• cor: white to beige
• solubilidade: DMSO: 15 mg/mL, clear
• temperatura de armazenamento: −20°C
• InChI: 1S/C20H22N2O4/c21-19(24)14-6-4-5-13(11-14)17-12-16(9-10-18(17)23)26-20(25)22-15-7-2-1-3-8-15/h4-6,9-12,15,23H,1-3,7-8H2,(H2,21,24)(H,22,25)
• chave InChI: CMEQHOXCIGFZNJ-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

URB937 is a fatty acid amide hydrolase (FAAH) inhibitor that is actively excluded from the CNS by the membrane transporter ABCG2. The ED₅₀ for inhibition of FAAH activity in the brain is 200 times higher than inhibition of renal FAAH activity. In vivo administration of URB937 elevates anandamide levels in peripheral tissues, and attenuates acetic acid-induced writhing, hyperalgesia in a sciatic nerve ligation model, and pain and edema in carrageenan injected paws.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable