Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

07-413

Sigma-Aldrich

Anti-dimethyl-Arginine Antibody, symmetric (SYM11)

Upstate®, from rabbit

Sinônimo(s):

Anti-SYM11, Anti-dimethyl-Arginine, Symmetric Dimethyl-Arginine Ab

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(1)

About This Item

Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

purified antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

reatividade de espécies

human, mouse

fabricante/nome comercial

Upstate®

técnica(s)

western blot: suitable

Isotipo

IgG

Condições de expedição

dry ice

modificação pós-traducional do alvo

unmodified

Descrição geral

Symmetrical dimethylated arginine (sDMA) is a product of the post-translational modification, arginine methylation. sDMA is a structural isomer of asymmetric dimethylarginine.

Especificidade

SmD3 at ~16kDa, and other proteins that contain arginines that are symmetrically dimethylated

Imunogênio

peptide corresponding to amino acids 99-119 of Small nuclear ribonucleoprotein SmD3.

Aplicação

Anti-dimethyl-Arginine Antibody, symmetric (SYM11) has been used in:
  • co-immunoprecipitation (co-IP)
  • western blot analysis
  • immunoprecipitation

Ações bioquímicas/fisiológicas

Symmetrical dimethylarginine (sDMA) is a competitor of arginine transport and is eliminated through renal excretion. sDMA serves as a marker to indicate the estimated glomerular filtration rate (GFR) and the coronary artery disease (CAD) severity. Elevated sDMA is associated with the risk of cardiovascular disease and mortality. It might also help in the early detection of chronic kidney disease. sDMA acts as an endogenous marker of renal function. It is associated with tumorigenesis.

Qualidade

routinely evaluated by immunoblot in RIPA lysates from Jurkat cells

Descrição-alvo

~16 kDa

forma física

Format: Purified

Nota de análise

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Informações legais

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Jérémy Dufourt et al.
Nature communications, 8(1), 1305-1305 (2017-11-05)
Piwi-interacting RNAs (piRNAs) and PIWI proteins play a crucial role in germ cells by repressing transposable elements and regulating gene expression. In Drosophila, maternal piRNAs are loaded into the embryo mostly bound to the PIWI protein Aubergine (Aub). Aub targets
Ming Gao et al.
EMBO reports, 16(3), 379-386 (2015-01-21)
Germ cells give rise to all cell lineages in the next-generation and are responsible for the continuity of life. In a variety of organisms, germ cells and stem cells contain large ribonucleoprotein granules. Although these particles were discovered more than
Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing.
Deng, X; Gu, L; Liu, C; Lu, T; Lu, F; Lu, Z; Cui, P; Pei, Y; Wang, B; Hu, S; Cao, X
Proceedings of the National Academy of Sciences of the USA null
Hao Yang et al.
Oncotarget, 7(44), 72131-72147 (2016-10-07)
Although cancer cells are known to be "addicted" to glucose, the effect of glucose in proliferation of these cells remains elusive. Here, we report that upon glucose induction, protein arginine methyltransferase 5 (PRMT5) exerts a profound effect on the G1-S
Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing.
Boisvert, Francois-Michel, et al.
The Journal of cell biology, 159, 957-969 (2002)
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica