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SML0341

Sigma-Aldrich

Importazole

≥98% (HPLC)

Sinônimo(s):

N-(1-Phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine

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About This Item

Fórmula empírica (Notação de Hill):
C20H22N4
Número CAS:
662163-81-7
Peso molecular:
318.42
Número MDL:
MFCD04077630
Código UNSPSC:
12352200
ID de substância PubChem:
329825346
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to beige

solubilidade

DMSO: >5 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C1=CC=CC=C1)NC2=NC(N3CCCC3)=NC4=C2C=CC=C4

InChI

1S/C20H22N4/c1-15(16-9-3-2-4-10-16)21-19-17-11-5-6-12-18(17)22-20(23-19)24-13-7-8-14-24/h2-6,9-12,15H,7-8,13-14H2,1H3,(H,21,22,23)

chave InChI

HKGJEZIGDHFJFL-UHFFFAOYSA-N

Aplicação

Importazole has been used:
  • to inhibit importin-β and to elucidate the mechanism of enhanced nuclear localization of heat shock protein 70 (HSP70) by vaccinia-related kinase 3 (VRK3)
  • to treat COS?7 cells transfected with the expressing vectors of WT HNF4α , S78A, and S78D to study its effect
  • as a KPNB inhibitor to determine whether CREB-regulated co-activator 1 (CRTC1) would be escorted into the nucleus by the classical nuclear localizing sequence (NLS)- dependent machinery
  • as a functional inhibitor of Importin β in embryo treatment
  • as an importin inhibitor to treat the transfected H1299 cells to block nuclear translocation of phosphorylated p53-RS

Ações bioquímicas/fisiológicas

Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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High fat diet-induced oxidative stress blocks hepatocyte nuclear factor 4alpha and leads to hepatic steatosis in mice
Yu D, et al.
Journal of Cellular Physiology, 233(6), 4770-4782 (2018)
Mutant p53 gains its function via c-Myc activation upon CDK4 phosphorylation at serine 249 and consequent PIN1 binding
Liao P, et al.
Molecular Cell, 68(6), 1134-1146 (2017)
Essential elements for translation: the germline factor Vasa functions broadly in somatic cells
Yajima M and Wessel GM
Development, 142(11), 1960-1970 (2015)
VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Abeta accumulation via enhancement of ERK phosphatase VHR activity
Song H, et al.
Scientific reports, 6, 38452-38452 (2016)
Shengping Huang et al.
The Journal of biological chemistry, 296, 100117-100117 (2020-11-26)
Kinesin is part of the microtubule-binding motor protein superfamily, which serves important roles in cell division and intraorganellar transport. The heterotrimeric kinesin-2, consisting of the heterodimeric motor subunits, kinesin family member 3A/3B (KIF3A/3B), and kinesin-associated protein 3 (KAP3), is highly
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