SML0128

M30 dihydrochloride

≥98% (HPLC)

• Sinônimo(s): 5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride, M-30 dihydrochloride, VAR10300 dihydrochloride
• Fórmula empírica (Notação de Hill): C₁₄H₁₄N₂O · 2HCl
• Número CAS: 64821-19-8
• Peso molecular: 299.20
• Número MDL: MFCD20488063
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825178
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: green-yellow
• solubilidade: DMSO, heptane and xylene: ≥21 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12
• InChI: 1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H
• chave InChI: XJNICPXVRPOSSO-UHFFFAOYSA-N

Descrição

Aplicação

M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies.

Ações bioquímicas/fisiológicas

M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.

Site-activated iron chelator and monoamine oxidase (MAO) inhibitor; neuroprotective and anti-apoptotic

Características e benefícios

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS05,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H318
• Declarações de precaução: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Classificações de perigo: Acute Tox. 4 Oral - Eye Dam. 1
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable