SML0025

Safinamide mesylate salt

≥98% (HPLC)

• Sinônimo(s): (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;
• Fórmula empírica (Notação de Hill): C₁₇H₁₉FN₂O₂ · xCH₄O₃S
• Número CAS: 202825-46-5
• Peso molecular: 302.34 (free base basis)
• Número MDL: MFCD15145475
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825096
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• atividade óptica: [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
• cor: white to tan
• solubilidade: H₂O: ≥15 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
• InChI: 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
• chave InChI: YKOCHIUQOBQIAC-YDALLXLXSA-N
• Informações sobre genes: human ... MAOB(4129)

Descrição

Aplicação

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).

Safinamide mesylate salt may be used in cell signaling studies.

Ações bioquímicas/fisiológicas

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

Características e benefícios

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302,H319,H361d
• Declarações de precaução: P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Classificações de perigo: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable