SCP0137
Endothelin Receptor Antagonist W 7338A
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About This Item
Fórmula empírica (Notação de Hill):
C30H42N6O7
Peso molecular:
598.69
Código UNSPSC:
12352200
NACRES:
NA.32
Produtos recomendados
![(2R)-2-[[(2R)-2-([(2S)-2-[(1-AZEPANYLCARBONYL)AMINO]-4-METHYLPENTANOYL]AMINO)-3-(1-METHYL-1H-INDOL-3-YL)PROPANOYL]AMINO]-3-(2-PYRIDINYL)PROPANOIC ACID AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/603/815/df767102-f4fb-4cb9-86d8-c9c28f9f88fa/640/df767102-f4fb-4cb9-86d8-c9c28f9f88fa.png)
Ensaio
≥95% (HPLC)
forma
lyophilized
composição
Peptide Content, ≥85%
condição de armazenamento
protect from light
temperatura de armazenamento
−20°C
Amino Acid Sequence
Glu-Ala-Val-Leu-Trp
Aplicação
Endothelin Receptor Antagonist W-7338A isolated from Streptomyces sp. No. 7338 is used as an endothelin receptor antagonist.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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S Miyata et al.
The Journal of antibiotics, 45(1), 83-87 (1992-01-01)
WS-7338, produced by Streptomyces sp. No. 7338, was found to be a competitive and specific antagonist against ET-1 receptors in in vitro studies and WS-7338 B is also active in vivo. Furthermore, WS-7338 B was a specific antagonist for vascular
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. III. Structures of WS-7338 A, B, C and D and total synthesis of WS-7338 B.
S Miyata et al.
The Journal of antibiotics, 45(5), 788-791 (1992-05-01)
S Miyata et al.
The Journal of antibiotics, 45(1), 74-82 (1992-01-01)
WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC.
Endothelin receptor antagonists: an overview of their synthesis and structure-activity relationship.
Javed Iqbal et al.
Mini reviews in medicinal chemistry, 5(4), 381-408 (2005-04-28)
Endothelins (ETs) are potent vasoconstrictor peptides and are associated with several disease states like pulmonary hypertension, systemic hypertension and heart failure. Endothelin-1 (ET-1) is the first member of the family and it has the receptor subtypes known as ETA and
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