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Documentos Principais

SCP0136

Endothelin β Receptor Antagonist IRL 1038

Name: Endothelin β Receptor Antagonist IRL 1038
Brand: SIGMA

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About This Item

Fórmula empírica (Notação de Hill):

C₆₈H₉₂N₁₄O₁₅S₂

Peso molecular:

1409.67

Código UNSPSC:

12352200

NACRES:

NA.32

Produtos recomendados

Slide 1 of 1

1 of 1

Sigma-Aldrich

RAB0507

Human VEGF-A ELISA Kit

Ensaio

≥95% (HPLC)

forma

lyophilized

composição

Peptide Content, ≥67%

condição de armazenamento

protect from light

temperatura de armazenamento

−20°C

Amino Acid Sequence

Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp

Aplicação

IRL-1038 is used as a specific endothelin-B receptor (ET(B)-R) antagonist/blocker.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Effects of specific endothelin-1 receptor antagonists on proliferation and fibronectin production of glomerular mesangial cells stimulated with Angiotensin II.

Hung-Tien Kuo et al.

The Kaohsiung journal of medical sciences, 22(8), 371-376 (2006-08-17)

Angiotensin II (Ang-II) is a potent vasoactive hormone, which plays an important role in the pathogenesis of glomerulosclerosis. Ang-II activates many cytokine systems in the kidney. Recent studies indicate that Ang-II is closely related to the activation of the endothelin-1

Regulation of vasopressin secretion by ETA and ETB receptors in compartmentalized rat hypothalamo-neurohypophysial explants.

Noreen F Rossi

American journal of physiology. Endocrinology and metabolism, 286(4), E535-E541 (2003-12-11)

The endothelins (ET) have been implicated in vasopressin (AVP) release in vivo and in vitro. The effects of ET in this system are complex, and the net AVP secretory response likely depends on a unique combination of ET isoform, ET

Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein.

Guo-lin Zhang et al.

Acta pharmacologica Sinica, 32(2), 223-229 (2011-02-05)

To investigate which endothelin receptors mediated isoproterenol (ISO)-induced downregulation of FKBP12.6/12 in cardiomyocytes and study whether argirhein, a novel compound containing rhein and L-arginine that has anti-inflammatory activity, could reverse the downregulation of FKBP12.6/12 induced by ISO. Neonatal rat cardiomyocytes

Endothelin receptor alterations in equine airway hyperreactivity.

Changaram S Venugopal et al.

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 70(1), 50-57 (2006-03-22)

The purpose of this study was to evaluate the role of endothelin-1 (ET-1) and its receptors in the airway hyperreactivity of horses with obstructive pulmonary disease associated with summer pasture (SPAOPD). The right diaphragmatic lobe of the lung of 8

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