SAB5500002

Anti-SMA antibody, Rabbit monoclonal

clone SP171, recombinant, expressed in proprietary host, affinity isolated antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• Nível de qualidade: 100
• recombinante: expressed in proprietary host
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: SP171, monoclonal
• reatividade de espécies: human (tested)
• reatividade da espécie (prevista por homologia): rabbit, rat, bovine, chicken, mouse, pig
• técnica(s): immunoblotting: 1:50; immunohistochemistry: 1:200
• Isotipo: IgG
• nº de adesão UniProt: P62736
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... ACTA2(59)

Descrição

Descrição geral

Smooth muscle actin-α (SMA), also known as α2-smooth muscle actin (ACTA2), is a cytoskeleton protein in smooth muscle cells. It is encoded by the gene mapped to human chromosome 10q23.31. SMA is a vascular smooth muscle specific isoform,

Smooth muscle actin-alpha (SMA) is a cytoskeleton protein in smooth muscle cells and their derived tumors such as leiomyoma and leiomyosarcoma. It is also expressed in myoepithelial cells of the breast and salivary gland, but not in fibroblasts, striated muscle, and myocardium.

Imunogênio

Synthetic peptide near the N-terminus of human SMA protein.

Aplicação

Anti-SMA antibody, Rabbit monoclonal has been used in:

• western blotting
• immunohistochemistry
• immunofluorescence

Ações bioquímicas/fisiológicas

Smooth muscle actin-α (SMA)/ α2-smooth muscle actin (ACTA2) interacts with β-myosin heavy chain and facilitates vascular smooth muscle cell contraction. The encoded protein regulates c-MET (tyrosine-protein kinase Met) and focal adhesion kinase (FAK) expression in human lung adenocarcinoma cells, which positively and selectively mediates tumor progression. Thus, SMA can be used as a potential prognostic biomarker and/or target for treating metastatic lung adenocarcinoma. Mutation in the gene is associated with the development of patent ductus arteriosus (PDA), bicuspid aortic valve (BAV), iris flocculi, livedo reticularis, cerebrovascular accident (CVA) and stenosis of the aortic vasa vasorum. In addition, variation in the gene expression leads to thoracic aortic aneurysms and dissections (TAAD).

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable