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SAB4700313

Sigma-Aldrich

Monoclonal Anti-HLA-G-Biotin antibody produced in mouse

clone MEM-G/9, purified immunoglobulin, buffered aqueous solution

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

conjugado

biotin conjugate

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

MEM-G/9, monoclonal

Formulário

buffered aqueous solution

reatividade de espécies

human

concentração

1 mg/mL

técnica(s)

flow cytometry: suitable

Isotipo

IgG1

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... HLA-G(3135)

Descrição geral

The antibody MEM-G/9 reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody MEM-G/9 is standard reagent thoroughly validated during 3rd International Conference on HLA-G (Paris, 2003).
Histocompatibility leukocyte antigen–G (HLA-G), a naturally occurring immunosuppressive molecule, is located on human chromosome 6p21. HLA-G gene codes for a tolerogenic protein.

Imunogênio

Recombinant human HLA-G refolded with beta2-microglobulin and peptide

Aplicação

The reagent is designed for Flow Cytometry analysis of cells expressing HLA-G molecule on the cell surface using a 1:1000 dilution. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

Ações bioquímicas/fisiológicas

Histocompatibility leukocyte antigen–G (HLA-G) plays an important role in preventing the activities of natural killer (NK) cell and inducing immune escape. It has the ability to block immune competent cells and innate and adaptive immune system. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Human Leukocyte Antigen-G Inhibits the Anti-Tumor Effect of Natural Killer Cells via Immunoglobulin-Like Transcript 2 in Gastric Cancer.
Wan R, et al.
Cellular Physiology and Biochemistry, 44(5), 1828-1841 (2017)
Recipient HLA-G+ 3142 CC genotype and concentrations of soluble HLA-G impact on occurrence of CMV infection after living-donor kidney transplantation.
Guberina H, et al.
International Journal of Molecular Sciences, 18(11), 2338-2338 (2017)
HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia.
Caocci G, et al.
Leukemia Research, 61, 1-5 (2017)
Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue.
Wei X and Orr HT
Human immunology, 29(2), 131-142 (1990)
Ana S López et al.
Molecular immunology, 43(14), 2151-2160 (2006-02-24)
Dendritic cells (DC) are strong inducers of immunity but they can also be tolerogenic. During monocyte differentiation to DC the immunosuppressive indoleamine-2,3-dioxygenase (IDO) is induced. IDO degrades Trp to kynurenine, which is further metabolized to 3-hydroxyanthranilic acid. DC can also

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