SAB4700313
Monoclonal Anti-HLA-G-Biotin antibody produced in mouse
clone MEM-G/9, purified immunoglobulin, buffered aqueous solution
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
biotin conjugate
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
MEM-G/9, monoclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
concentração
1 mg/mL
técnica(s)
flow cytometry: suitable
Isotipo
IgG1
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... HLA-G(3135)
Categorias relacionadas
Descrição geral
The antibody MEM-G/9 reacts with native form of human HLA-G1 on the cell surface as well as with soluble HLA-G5 isoform in its beta2-microglobulin associated form. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells. The antibody MEM-G/9 is standard reagent thoroughly validated during 3rd International Conference on HLA-G (Paris, 2003).
Histocompatibility leukocyte antigen–G (HLA-G), a naturally occurring immunosuppressive molecule, is located on human chromosome 6p21. HLA-G gene codes for a tolerogenic protein.
Histocompatibility leukocyte antigen–G (HLA-G), a naturally occurring immunosuppressive molecule, is located on human chromosome 6p21. HLA-G gene codes for a tolerogenic protein.
Imunogênio
Recombinant human HLA-G refolded with beta2-microglobulin and peptide
Aplicação
The reagent is designed for Flow Cytometry analysis of cells expressing HLA-G molecule on the cell surface using a 1:1000 dilution. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Ações bioquímicas/fisiológicas
Histocompatibility leukocyte antigen–G (HLA-G) plays an important role in preventing the activities of natural killer (NK) cell and inducing immune escape. It has the ability to block immune competent cells and innate and adaptive immune system. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.
Características e benefícios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
forma física
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Human Leukocyte Antigen-G Inhibits the Anti-Tumor Effect of Natural Killer Cells via Immunoglobulin-Like Transcript 2 in Gastric Cancer.
Wan R, et al.
Cellular Physiology and Biochemistry, 44(5), 1828-1841 (2017)
Recipient HLA-G+ 3142 CC genotype and concentrations of soluble HLA-G impact on occurrence of CMV infection after living-donor kidney transplantation.
Guberina H, et al.
International Journal of Molecular Sciences, 18(11), 2338-2338 (2017)
HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia.
Caocci G, et al.
Leukemia Research, 61, 1-5 (2017)
Differential expression of HLA-E, HLA-F, and HLA-G transcripts in human tissue.
Wei X and Orr HT
Human immunology, 29(2), 131-142 (1990)
Ana S López et al.
Molecular immunology, 43(14), 2151-2160 (2006-02-24)
Dendritic cells (DC) are strong inducers of immunity but they can also be tolerogenic. During monocyte differentiation to DC the immunosuppressive indoleamine-2,3-dioxygenase (IDO) is induced. IDO degrades Trp to kynurenine, which is further metabolized to 3-hydroxyanthranilic acid. DC can also
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