SAB4700062
Monoclonal Anti-CD4-FITC , (N-terminal) antibody produced in mouse
clone MEM-241, purified immunoglobulin, buffered aqueous solution
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.44
clone:
MEM-241, monoclonal
application:
FACS
reatividade de espécies:
human
técnica(s):
flow cytometry: suitable
citations:
4
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
FITC conjugate
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
MEM-241, monoclonal
Formulário
buffered aqueous solution
reatividade de espécies
human
técnica(s)
flow cytometry: suitable
Isotipo
IgG1
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
2-8°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CD4(920)
Descrição geral
Cluster of differentiation 4 (CD4) molecule is encoded by the gene mapped to human chromosome 12p13.31. The encoded protein is mainly localized on the surface of specific leukocytes. CD4 is characterized with a four ecto-domains (D1-D4) of which D1, D2 and D4 contain disulfide bonds.
The antibody MEM-241 recognizes CD4 antigen, a 55 kDa transmebrane glycoprotein expressed on a subset of T lymphocytes ("helper" T-cells) and also on monocytes, tissue macrophages and granulocytes.
Imunogênio
2 N-terminal domains of human CD4 fused to human IgG1 Fc
Aplicação
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Ações bioquímicas/fisiológicas
Cluster of differentiation 4 (CD4) facilitates the activation of immunostimulatory T-cells. It serves as a primary receptor for human immunodeficiency virus (HIV)-1 entry. The encoded protein also plays a key role in altering cell elasticity. Elevated expression of soluble CD4 has been observed in patients of infectious and chronic inflammatory diseases and rheumatoid arthritis (RA). Thus, this protein can be used as a potential diagnostic marker for the development of RA.
Características e benefícios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
forma física
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
The role of CD4 on mechanical properties of live cell membrane
Bui VC and Nguyen TH
Journal of Biomedical Materials Research Part A, 104(1), 239-244 (2016)
Disease severity in rheumatoid arthritis: Relationships of plasma tumor necrosis factor-α, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures
Beckham JC, et al.
Journal of clinical immunology, 12(5), 353-361 (1992)
Ravi Tandon et al.
AIDS research and human retroviruses, 30(7), 654-664 (2014-05-03)
Galectin-9 (Gal-9) is a β-galactosidase-binding lectin that promotes apoptosis, tissue inflammation, and T cell immune exhaustion, and alters HIV infection in part through engagement with the T cell immunoglobulin mucin domain-3 (Tim-3) receptor and protein disulfide isomerases (PDI). Gal-9 was
Yimei Liu et al.
Immunology letters, 161(1), 50-56 (2014-04-29)
The autoimmune regulator (AIRE) regulates autoimmunity and self-antigen expression, such as acetylcholine receptor (AchR), in the thymus. Regulatory T cells (Tregs) can down-regulate autoimmunity, but also promote tumor growth. The objective of this study was to examine the levels of
Isochromosomes 12p and 9p: parental origin and possible mechanisms of formation
Dutly F, et al.
European Journal of Human Genetics, 6(2), 140-144 (1998)
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