SAB4502691
Anti-S6K antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
70 kDa ribosomal protein S6 kinase 1, Ribosomal protein S6 kinase I, S6K, S6K1, p70 S6 kinase α
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
forma
buffered aqueous solution
peso molecular
antigen 59 kDa
reatividade de espécies
rat, human, mouse
concentração
~1 mg/mL
técnica(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... RPS6KB1(6198)
Descrição geral
Ribosomal protein S6 kinase B1 (RPS6KB1) also known as S6Ka or S6K1 is an isoform of S6 kinases, which belong to AGC serine/threonine kinases of the ribosomal S6 kinase (RSK) family. S6K1 is encoded by the gene mapped to human chromosome 17q23. S6K1 is activated on phosphorylation of its domains, which include T-loop and hydrophobic motif and Ser-Pro/Thr-Pro residues at C- terminal.
Imunogênio
The antiserum was produced against synthesized peptide derived from human S6K.
Immunogen Range: 261-310
Immunogen Range: 261-310
Ações bioquímicas/fisiológicas
Ribosomal protein S6 kinase B1 (RPS6KB1), or S6K1, regulates cell size and progression through cell cycle. It also inhibits pro-apoptotic protein bcl-2-associated death promoter (BAD) and promotes cell survival. mTORC1 (mammalian TORC1) phosphorylates and activates S6K1, mTORC1-S6K1 complex regulates various cellular processes, such as transcription, translation, protein and lipid synthesis, cell growth/size and cell metabolism. Overexpression of S6 kinase 1 (S6K1) leads to many disorders , including diabetes, aging, and cancer. Development of organometallic S6K1 inhibitors such as EM5 and FL772, might be a potential method for the treatment of diseases caused by aberrant activity of S6K1. The increased expression of S6K1 in obesity results in adipose tissue dysfunction via a close association with insulin resistance and inflammation development. Elevated expression of S6K1 is observed in breast cancer patients.
Características e benefícios
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forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
R M Biondi et al.
The EMBO journal, 20(16), 4380-4390 (2001-08-14)
PKB/Akt, S6K1 and SGK are related protein kinases activated in a PI 3-kinase-dependent manner in response to insulin/growth factors signalling. Activation entails phosphorylation of these kinases at two residues, the T-loop and the hydrophobic motif. PDK1 activates S6K, SGK and
Brian Magnuson et al.
The Biochemical journal, 441(1), 1-21 (2011-12-16)
The ribosomal protein S6K (S6 kinase) represents an extensively studied effector of the TORC1 [TOR (target of rapamycin) complex 1], which possesses important yet incompletely defined roles in cellular and organismal physiology. TORC1 functions as an environmental sensor by integrating
F J Couch et al.
Cancer research, 59(7), 1408-1411 (1999-04-10)
The application of comparative genomic hybridization to the analysis of genetic abnormalities in breast carcinoma has consistently revealed that chromosome region 17q22-24 is a frequent site of gene amplification in this type of cancer. As part of an examination of
Andrea R Marti et al.
Frontiers in neural circuits, 11, 70-70 (2017-11-01)
Millions of people worldwide work during the night, resulting in disturbed circadian rhythms and sleep loss. This may cause deficits in cognitive functions, impaired alertness and increased risk of errors and accidents. Disturbed circadian rhythmicity resulting from night shift work
Jie Qin et al.
Journal of medicinal chemistry, 58(1), 305-314 (2014-10-31)
Aberrant activation of S6 kinase 1 (S6K1) is found in many diseases, including diabetes, aging, and cancer. We developed ATP competitive organometallic kinase inhibitors, EM5 and FL772, which are inspired by the structure of the pan-kinase inhibitor staurosporine, to specifically
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