SAB4502419
Anti-Peripherin antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
PERI, PRPH
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
conjugado
unconjugated
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
clone
polyclonal
Formulário
buffered aqueous solution
peso molecular
antigen 53 kDa
reatividade de espécies
rat, human
concentração
~1 mg/mL
técnica(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
nº de adesão NCBI
nº de adesão UniProt
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... PRPH(5630)
Descrição geral
Anti-Peripherin antibody detects endogenous levels of total Peripherin protein.
The PRPH (peripherin) gene is mapped to human chromosome 12q13.12. This gene codes for a 57 kDa intermediate filament protein. Peripherin is predominantly expressed in the peripheral neurons.
Imunogênio
The antiserum was produced against synthesized peptide derived from human Peripherin.
Immunogen Range: 421-470
Immunogen Range: 421-470
Ações bioquímicas/fisiológicas
Peripherin is known to be associated with the mechanism of organelle transport, function and positioning. It also forms an important part of the cytoskeleton. Mutation in PRPH (peripherin) is observed in amyotrophic lateral sclerosis. Peripherin participates in the elongation of motor axons. Upregulation of PRPH is noticed in neuronal injury.
Características e benefícios
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forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Joshua J Emrick et al.
Proceedings of the National Academy of Sciences of the United States of America, 115(51), E12091-E12100 (2018-11-23)
Atopic dermatitis (AD) is the most common skin disease in children. It is characterized by relapsing inflammation, skin-barrier defects, and intractable itch. However, the pathophysiology of itch in AD remains enigmatic. Here, we examine the contribution of Tmem79, an orphan
Paulo Victor Sgobbi de Souza et al.
Arquivos de neuro-psiquiatria, 73(12), 1026-1037 (2015-10-16)
Amyotrophic lateral sclerosis represents the most common neurodegenerative disease leading to upper and lower motor neuron compromise. Although the vast majority of cases are sporadic, substantial gain has been observed in the knowledge of the genetic forms of the disease
Charcot-Marie-Tooth type 2B disease-causing RAB7A mutant proteins show altered interaction with the neuronal intermediate filament peripherin.
Cogli L
Acta Neuropathologica, 125(2), 257-272 (2013)
Jesse McLean et al.
Journal of neurochemistry, 114(4), 1177-1192 (2010-06-11)
Peripherin is a type III intermediate filament protein that is up-regulated during neuronal injury and is a major component of pathological inclusions found within degenerating motor neurons of patients with amyotrophic lateral sclerosis (ALS). The relationship between these inclusions and
Inhibition of Poly(A)-binding protein with a synthetic RNA mimic reduces pain sensitization in mice.
Paulino Barragán-Iglesias et al.
Nature communications, 9(1), 10-10 (2018-01-04)
Nociceptors rely on cap-dependent translation to rapidly induce protein synthesis in response to pro-inflammatory signals. Comparatively little is known regarding the role of the regulatory factors bound to the 3' end of mRNA in nociceptor sensitization. Poly(A)-binding protein (PABP) stimulates translation
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