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SAB4300270

Sigma-Aldrich

Anti-phospho-AURKA (pThr288) antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

Anti-AIK antibody produced in rabbit, Anti-ARK1 antibody produced in rabbit, Anti-AURA antibody produced in rabbit, Anti-AURORA2 antibody produced in rabbit, Anti-aurora kinase A antibody produced in rabbit

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About This Item

Número MDL:
MFCD06411780
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

~48 kDa

reatividade de espécies

mouse, human

concentração

1 mg/mL

técnica(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100

Isotipo

IgG

sequência de imunogênio

(R-T-TP-L-M)

nº de adesão NCBI

NP_003591.2

nº de adesão UniProt

O14965

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

phosphorylation (pThr288)

Informações sobre genes

human ... AURKA(6790)

Imunogênio

Peptide sequence around phosphorylation site of threonine 288 (R-T-T(p)-L-M), according to the protein AURKA.

Aplicação

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Descrição-alvo

Contributes to the regulation of cell cycle progression. Required for normal mitosis. Associates with the centrosome and the spindle microtubules during mitosis and functions in centrosome maturation, spindle assembly, maintenance of spindle bipolarity, centrosome separation and mitotic checkpoint control. Phosphorylates numerous target proteins, including ARHGEF2, BRCA1, KIF2A, NDEL1, PARD3, PLK1 and BORA. Regulates KIF2A tubulin depolymerase activity By similarity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization.

forma física

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Se-Chun Liao et al.
Nutrients, 11(6) (2019-06-27)
Curcumin is a polyphenol derived from curcumin longa that exhibits anticancer and anti-inflammatory properties. The consumption of foods at supernutritional levels to obtain health benefits may paradoxically result in negative health outcomes. In the present study, multiple targeting characteristics of
Liwei Li et al.
International journal of molecular medicine, 41(6), 3629-3641 (2018-03-08)
Gastric adenocarcinoma remains a life‑threatening disease, emphasizing the importance of gaining an improved understanding of signaling pathways involved in this disease, which can lead to the development of novel therapeutic methods targeting common molecular pathways shared across different types of
Li-Yun Yang et al.
Head & neck, 41(7), 2239-2248 (2019-02-02)
Chemotherapy resistance was an important tumor metastasis mechanism. Cell Counting Kit-8 assay and plate colony formation assay were applied to examine the proliferation of laryngeal squamous cell carcinoma (LSCC). Immunofluorescent staining and Western blotting were carried out to show the
Suqin Shen et al.
Cell cycle (Georgetown, Tex.), 18(18), 2228-2238 (2019-07-31)
Aurora-A is a serine/threonine kinase, which is overexpressed in multiple human cancers and plays a key role in tumorigenesis and tumor development. In this study, we found that the receptor of activated C-kinase1 (RACK1), an important regulator of biological functions
Yi-Ting Chen et al.
Cancers, 12(10) (2020-10-11)
Analysis of various public databases revealed that HRAS gene mutation frequency and mRNA expression are higher in bladder urothelial carcinoma. Further analysis revealed the roles of oncogenic HRAS, autophagy, and cell senescence signaling in bladder cancer cells sensitized to the
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