SAB4200824

Anti-TFE3 antibody, Mouse monoclonal

clone TFE3-37, purified from hybridoma cell culture

• Sinônimo(s): Class E basic helix-loop-helix protein 33, Transcription factor E3, bHLHe33
• Código UNSPSC: 12352203
• NACRES: NA.43

Propriedades

• fonte biológica: mouse
• forma do anticorpo: purified from hybridoma cell culture
• clone: TFE3-37, monoclonal
• Formulário: buffered aqueous solution
• peso molecular: 60 kDa
• reatividade de espécies: human, mouse, bovine, rat, canine
• embalagem: antibody small pack of 25 μL
• concentração: ~1 mg/mL
• técnica(s): immunoblotting: 1.5-3 μg/mL using human A549 cells extract
• Isotipo: IgG1
• nº de adesão UniProt: P19532
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... TFE3(7030)

Descrição

Descrição geral

Transcription factor E3 (TFE3), also known as Class E basic helix-loop-helix protein 33 (bHLHe33), is a transcriptional activator that mediates the enhancer-promoter interactions. TFE3 belongs to the MiT family of helix-loop-helix leucine zipper transcription factors, it is ubiquitously expressed and can directly associate with DNA as either homodimer or heterodimer which are formed with two other MiT family members, TFEB or TFEC.
TFE3 serve an important role in cell growth, cell proliferation, cellular adaptation to starvation and cellular response to ER stress. Under nutrient-rich conditions, TFE3 is located in the cytoplasm, and under starvation conditions or treatment with ER stressors, TFE3 rapidly translocates to the nuclear. In the nuclear localization, TFE3 mediates cellular adaptation to stress by simultaneously promoting lysosomal biogenesis, autophagy induction, as well as expression of critical mitochondrial and metabolic regulators. It been shown that TFE3 also participate in the transcriptional regulation of the innate immune response.
Pathogen infections promote TFE3 nuclear translocation, thus inducing In vivo expression of several cytokines and chemokines.

Aplicação

Anti-TFE3 antibody specifically recognizes TFE3 from human, mouse, rat, bovine and canine origin. The antibody may be used in various immunochemical techniques including Immunoblotting (~60 kDa). Detection of the TFE3 band by Immunoblotting is specifically inhibited by the immunizing peptide.

forma física

Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

Outras notas

Unless otherwise stated in our catalog our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Exoneração de responsabilidade

This product is for R&D use only, not for drug, household, or other uses.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable