SAB4200663
Anti-Copeptin antibody produced in rabbit
affinity isolated antibody
Sinônimo(s):
CT-proAVP
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About This Item
Código UNSPSC:
51111800
NACRES:
NA.41
Produtos recomendados
fonte biológica
rabbit
Nível de qualidade
forma do anticorpo
affinity isolated antibody
tipo de produto de anticorpo
primary antibodies
reatividade de espécies
human
concentração
~1 mg/mL
técnica(s)
immunoblotting: 0.25-0.5 μg/mL (recommended using recombinant human Copeptin trifluoroacetate)
immunohistochemistry: 20 μg/mL (recommended using mouse or human kidney sections)
immunoprecipitation (IP): 5-10 μg (recommended using recombinant human Copeptin trifluoroacetate (C8749).)
indirect ELISA: 0.25-0.5 μg/mL (recommended using human Copeptin trifluoroacetate (C8749) for coating.)
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... AVP(551)
Descrição geral
AVP or pre-proAVP, also known as, vasopressin-neurophysin 2-copeptin is one of the main hormones of the axis hypothalamic-pituitary adrenal. It is split into 3 chains: Arg-vasopressin, neurophysin-2 and copeptin. Copeptin is a glycopeptide with 39 amino acids, located at the C-terminal part of the pre-proAVP. It is secreted by the posterior pituitary gland and poured into the systemic circulation.
The gene AVP (arginine vasopressin) is mapped to human chromosome 20. It is an antidiurectic hormone which is produced by hypothalamic neurons.
Imunogênio
a synthetic peptide corresponding to the C-terminal region of human Copeptin
Aplicação
Anti-Copeptin antibody produced in rabbit has been used in various immunochemical techniques including :
- immunohistochemistry
- immunoblotting
- immunoprecipitation
- enzyme linked immunosorbent assay (ELISA)
Ações bioquímicas/fisiológicas
Copeptin concentration directly reflects AVP activation and serves as a biomarker of the AVP system. Altered copeptin levels are implicated in stroke, sudden death and cardiovascular events. It can also be used as a biomarker for a list of illnesses, such as acute myocardial infarction (AMI), vasodilatory shock, metabolic syndrome, diabetes insipidus, diabetes mellitus, sepsis, septic shock, lower respiratory tract infections, hyponatremia, acute dyspnea, autosomal dominant polycystic kidney disease (ADPKD), intracerebral hemorrhage, pulmonary arterial hypertension (PAH) and head injury.
The gene AVP (arginine vasopressin) encodes preprovasopressin which is processed into vasopressin, neurophysin II and glycoprotein (copeptin). Mutations in it are associated with neurohypophyseal diabetes insipidus. It also plays a crucial role in social mannerism, such as recognition, aggression, reproduction and parenting. The levels of circulating copeptin is higher in children suffering from febrile seizures.
forma física
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Copeptin and its potential role in diagnosis and prognosis of various diseases
Dobvsa L and Cullen EK
Biochemical Medicine, 23(2), 172-190 (2013)
Jia Jia Liu et al.
PloS one, 10(8), e0136436-e0136436 (2015-08-22)
Arginine vasopressin (AVP) plays a role in social behavior, through receptor AVPR1A. The promoter polymorphism AVPR1A RS3 has been associated with human social behaviors, and with acute response to stress. Here, the relationships between AVPR1A RS3, early-life stressors, and social
Nils P Nickel et al.
Respiratory research, 14, 130-130 (2013-11-21)
To determine the levels of circulating copeptin in patients with pulmonary arterial hypertension (PAH), and to evaluate its relation with disease severity, outcome and response to treatment. Vasopressin is a key regulator of body fluid homeostasis. The co-secreted protein copeptin
Wiebke Fenske et al.
Journal of the American Society of Nephrology : JASN, 22(4), 782-790 (2011-03-19)
In ESRD, the neurohormone arginine vasopressin (AVP) may act primarily through V1a and V1b receptors, which promote vasoconstriction, myocardial hypertrophy, and release of adrenocorticotropic hormone. The preanalytical instability of AVP limits the investigation of whether this hormone associates with cardiovascular
Benjamin Stöcklin et al.
PloS one, 10(4), e0124663-e0124663 (2015-04-22)
Accurate diagnosis of febrile seizures in children presenting after paroxysmal episodes associated with fever, is hampered by the lack of objective postictal biomarkers. The aim of our study was to investigate whether FS are associated with increased levels of serum
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