SAB4200412

Anti-PLAUR/uPAR antibody, Mouse monoclonal

clone PL231, purified from hybridoma cell culture

• Sinônimo(s): Anti-CD87, Anti-Plasminogen activator urokinase receptor, Anti-UPAR, Anti-URKR, Monoclonal Anti-PLAUR/uPAR antibody produced in mouse
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• conjugado: unconjugated
• forma do anticorpo: purified from hybridoma cell culture
• tipo de produto de anticorpo: primary antibodies
• clone: PL231, monoclonal
• forma: buffered aqueous solution
• peso molecular: antigen ~55 kDa
• reatividade de espécies: monkey, rat, canine, human, mouse
• validação aprimorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentração: ~1.0 mg/mL
• técnica(s): indirect immunofluorescence: suitable; western blot: 4.0-8.0 μg/mL using extracts of HL-60 cells
• Isotipo: IgG1
• nº de adesão UniProt: Q03405
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... PLAUR(5329)

Descrição

Descrição geral

Plasminogen activator, urokinase receptor (PLAUR) is a well-characterized receptor for matrix-degrading proteases. It is encoded by the gene mapped to human chromosome 19q13.31.

Imunogênio

peptide corresponding to a sequence at the C-terminus of human PLAUR/uPAR.

Aplicação

Monoclonal Anti-PLAUR/uPAR antibody produced in mouse has been used in Western blotting (WB).

Ações bioquímicas/fisiológicas

Plasminogen activator, urokinase receptor (PLAUR) plays a vital role in tumor cell invasion, angiogenesis and metastasis. It acts as a key regulator of cell-surface plasminogen activator. It is implicated in various normal and pathological processes. Elevated expression of the gene has been observed in various types of cancers, including head and neck squamous cell carcinoma (HNSCC). Thus, it is considered as an potent biomarker for targeted imaging or therapy. Upregulated expression of PLAUR leads to the progression of kidney disease in children.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable