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SAB4200191

Sigma-Aldrich

Anti-Septin 9 antibody, Rat monoclonal

clone Clone 1A6C2, purified from hybridoma cell culture

Sinônimo(s):

Anti-MLL, Anti-MSF, Anti-MSF1, Anti-NAPB, Anti-PEANUT-LIKE 4, Anti-PNUTL4, Anti-SEPT9, Anti-SINT1, Anti-SeptD1, Monoclonal Anti-Septin 9 antibody produced in rat

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rat

conjugado

unconjugated

forma do anticorpo

purified from hybridoma cell culture

tipo de produto de anticorpo

primary antibodies

clone

Clone 1A6C2, monoclonal

forma

buffered aqueous solution

peso molecular

~72 kDa

reatividade de espécies

human, rat, monkey, mouse

concentração

~1.0 mg/mL

técnica(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: 2.5-5.0 μg/mL using L929, HeLa, 3T3 and COS-7 cell extracts

Isotipo

IgG2a

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... SEPT9(10801)
mouse ... Sept9(53860)
rat ... Sept9(83788)

Descrição geral

Monoclonal Anti-Septin 9 (rat IgG2a isotype) is derived from the hybridoma 1A6C2 produced by the fusion of mouse myeloma cells and splenocytes from rat immunized with a synthetic peptide of corresponding to the N-terminus of rat Septin 9, conjugated to KLH. Septin 9 (SEPT9) is a member of the septin family (also designated MSF/eseptin/Sint1). This gene is mapped to human chromosome 17q25.

Imunogênio

synthetic peptide of corresponding to the N-terminus of rat Septin 9 conjugated to KLH

Aplicação

Monoclonal Anti-Septin 9 has been used in:
  • immunoblotting
  • immunocytochemistry
  • immunohistochemistry
  • immunofluorescence

Ações bioquímicas/fisiológicas

Septin 9 (SEPT9) has been implicated in tumorigenesis. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. In addition, SEPT9 is shown to be a DNA methylation-based biomarker, effectively discriminated colorectal cancer from normal specimens.

forma física

Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Polarity of neuronal membrane traffic requires sorting of kinesin motor cargo during entry into dendrites by a microtubule-associated septin
Karasmanis EP, et al.
Developmental Cell, 46(2), 204-218 (2018)
Mutations in SEPT9 cause hereditary neuralgic amyotrophy
Kuhlenbaumer G, et al.
Nature Genetics, 37(10), 1044-1044 (2005)
AML1 amplification and 17q25 deletion in a case of childhood acute lymphoblastic leukemia
Gulten T, et al.
Journal of Clinical Laboratory Analysis, 23(6), 368-371 (2009)
Detection of methylated SEPT9 in plasma is a reliable screening method for both left-and right-sided colon cancers
Toth K, et al.
PLoS ONE, 7(9), e46000-e46000 (2012)
Eva P Karasmanis et al.
Current biology : CB, 29(13), 2174-2182 (2019-06-18)
Abscission is the terminal step of mitosis that physically separates two daughter cells [1, 2]. Abscission requires the endocytic sorting complex required for transport (ESCRT), a molecular machinery of multiple subcomplexes (ESCRT-I/II/III) that promotes membrane remodeling and scission [3-5]. Recruitment
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