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Key Documents

SAB2500809

Sigma-Aldrich

Anti-PODXL antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

Anti-Gp200, Anti-MGC138240, Anti-PCLP, Anti-Podocalyxin-like

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

goat

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

reatividade de espécies

human, rat, mouse, canine

técnica(s)

indirect ELISA: suitable
western blot: suitable

nº de adesão UniProt

O00592

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... PODXL(5420)

Categorias relacionadas

Descrição geral

PODXL (podocalyxin like) is an anti-adhesive transmembrane protein which belongs to the sialomucin protein family. It is associated with cancer development and aggressiveness. The protein is expressed in various cells including epithelial cells of kidney glomeruli, vascular endothelial cells, hematopoietic stem cells and platelets. The gene encoding PODXL is localized on human chromosome 7q32.3.

Imunogênio

Peptide with sequence C-DNLTKDDLDEEEDTH from the C Terminus of the protein sequence according to NP_001018121.1 ; NP_005388.2.

Ações bioquímicas/fisiológicas

PODXL (podocalyxin like) acts as an anti-adhesion molecule in kidney open filtration pathways. It interacts with the actin-binding protein ezrin in cancer. Using ezrin and the bridging protein NHERF (Na+/H+) exchanger regulatory factor, it connects to the cytoskeleton to regulate cytoskeletal-related functions in tumor progression. In human, PODXL stimulates the cell adherence capacity to immobilized ligands and vascular endothelial cells in presence of integrins.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Podocalyxin increases the aggressive phenotype of breast and prostate cancer cells in vitro through its interaction with ezrin.
Susana L
Cancer Research (2007)
Genome wide analysis of novel copy number variations duplications/deletions of different epileptic patients in Saudi Arabia
Muhammad M
BMC Genomics (2015)
Li Ling et al.
International journal of molecular medicine, 41(5), 2704-2714 (2018-02-14)
Diabetic nephropathy (DN) is one of the most common complications associated with type I and II diabetes mellitus. Long noncoding RNAs (lncRNAs) have been implicated in various physiological and pathological processes, and recent evidence has demonstrated that they are involved in the process
Cheng-Wei Lin et al.
International journal of oncology, 45(2), 710-718 (2014-05-14)
Metastasis-mediated death remains a major challenge in cancer treatment due to the lack of identifiable biomarkers for early diagnosis. Identifying tumor-specific biomarkers is critical for the development of diagnostic and therapeutic tools. In the present study, we found that podocalyxin-like

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