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Key Documents

SAB1306301

Sigma-Aldrich

ANTI-PHOSPHO-CREB(S133) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinônimo(s):

CREB1, Cyclic AMP-responsive element-binding protein 1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

36688 Da

reatividade de espécies

human

técnica(s)

immunohistochemistry: 1:50-1:100
western blot: 1:1000

nº de adesão NCBI

NP_004370.1

nº de adesão UniProt

P16220

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

phosphorylation (pSer133)

Informações sobre genes

human ... CREB1(1385)

forma física

Supplied in PBS with 0.09% (W/V) sodium azide

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Jing Guo et al.
International journal of clinical and experimental medicine, 7(5), 1297-1306 (2014-07-06)
The mechanisms underlying the pathogenesis of intractable epilepsy (IE) are still unclear. This study aimed to investigate the role of phosphorylation of Cyclase Response Element Binding Protein (p-CREB)/microRNA-132 (miR-132) signal pathway in the epileptogenesis. Temporal lobe epilepsy (TLE) was induced
Seiko Yasuda et al.
Cellular and molecular neurobiology, 34(8), 1199-1208 (2014-08-27)
Depression-like behavior is often complicated by chronic pain. Antidepressants including imipramine (IMI) are widely used to treat chronic pain, but the mechanisms are not fully understood. Brain-derived neurotrophic factor (BDNF) is a neuromodulator that reduces depression by regulating synaptic transmission.
Miaojun Lai et al.
The international journal of neuropsychopharmacology, 17(9), 1397-1407 (2014-05-17)
Inhibition of phosphodiesterase-4 (PDE4), an enzyme that specifically hydrolyzes cyclic adenosine monophosphate (cAMP) increases intracellular cAMP/cAMP-response element binding protein (CREB) signaling. Activation of this signaling is considered as an important compensatory response that decreases motivational properties of drugs of abuse.
Ludmila Gaspar et al.
The European journal of neuroscience, 40(1), 2206-2215 (2014-06-06)
Various lines of evidence suggest a mechanistic role for altered cAMP-CREB (cAMP response element - binding protein) signaling in depressive and affective disorders. However, the establishment and validation of human inter-individual differences in this and other major signaling pathways has
Sven Akkerman et al.
PloS one, 9(11), e111692-e111692 (2014-11-06)
Drug effects are usually evaluated in animals housed under maximally standardized conditions. However, it is assumed that an enriched environment (EE) more closely resembles human conditions as compared to maximally standardized laboratory conditions. In the present study, we examined the
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