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S8251

Succinylcholine chloride dihydrate

Name: Succinylcholine chloride dihydrate
Brand: SIGMA

98.0-102.0%, solid

Sinônimo(s):

Bis(trimethylammonioethyl) succinate chloride, Succinyldicholine dichloride

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About This Item

Fórmula linear:

[(CH₃)₃NCH₂CH₂OCOCH₂]₂Cl₂ · 2H₂O

Número CAS:

6101-15-1

Peso molecular:

397.34

Beilstein:

3922827

Número CE:

200-747-4

Número MDL:

MFCD00150564

Código UNSPSC:

41116107

ID de substância PubChem:

24277873

NACRES:

NA.77

Ensaio

98.0-102.0%

forma

solid

cor

white

solubilidade

H₂O: complete 100 mg/ml, clear to slightly hazy, colorless
H₂O: soluble (unstable at pH > 9.)

originador

Novartis

cadeia de caracteres SMILES

O.O.[Cl-].[Cl-].C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C

InChI

1S/C14H30N2O4.2ClH.2H2O/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6;;;;/h7-12H2,1-6H3;2*1H;2*1H2/q+2;;;;/p-2

chave InChI

FFSBEIRFVXGRPR-UHFFFAOYSA-L

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Aplicação

Succinylcholine chloride dehydrate was used to study the mechanism of gating of Cys loop receptors in Xenopus laevis.^4,5

Ações bioquímicas/fisiológicas

Cholinergic antagonist which induces a long-lasting depolarization of the acetylcholine neuron membrane; neuromuscular blocking agent.

Succinylcholine is a cholinergic antagonist and a neuromuscular blocking agent. It induces depolarization of acetylcholine receptors on the muscle membrane and efflux of potassium from the muscle that leads to hypokalemia in individuals with upregulated expression of acetylcholine receptors.³

Características e benefícios

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Reconstituição

Solutions may be stored for several days at 4 °C.

Pictogramas

GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P301 + P310

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Using vertebral movement and intact paraspinal muscles to determine the distribution of intrafusal fiber innervation of muscle spindle afferents in the anesthetized cat.

William R Reed et al.

Experimental brain research, 225(2), 205-215 (2012-12-12)

Increasing our knowledge regarding intrafusal fiber distribution and physiology of paraspinal proprioceptors may provide key insights regarding proprioceptive deficits in trunk control associated with low back pain and lead to more effective clinical intervention. The use of vertebral movement as

Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms.

J A Jeevendra Martyn et al.

Anesthesiology, 104(1), 158-169 (2006-01-06)

Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated. In the normal innervated mature muscle, the acetylcholine receptors (AChRs) are located only in the junctional area. In certain

Effects of succinylcholine in an organotypic spinal cord-skeletal muscle coculture of embryonic mice.

Berthold Drexler et al.

Chemico-biological interactions, 206(3), 555-560 (2013-07-11)

Intoxication with organophosphorus compounds is an important clinical problem worldwide. Although the core treatments - atropine, oximes and diazepam - are defined, high case fatalities were reported for intoxication with organophosphorus insecticides. In particular the role of oximes is not

How can we improve mask ventilation in patients with obstructive sleep apnea during anesthesia induction?

Yumi Sato et al.

Journal of anesthesia, 27(1), 152-156 (2012-12-06)

Recent evidence suggests the possible development of difficult mask ventilation in patients with obstructive sleep apnea. Based on our current understanding of the pathophysiology of pharyngeal airway obstruction in obstructive sleep apnea patients, we conclude that anesthesiologists can decrease respiratory

The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2.

Brandon H Cline et al.

BMC neuroscience, 13, 110-110 (2012-09-20)

A number of epidemiological studies have established a link between insulin resistance and the prevalence of depression. The occurrence of depression was found to precede the onset of diabetes and was hypothesized to be associated with inherited inter-related insufficiency of

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