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S8197

Sigma-Aldrich

SMER28

>99% (HPLC), solid

Sinônimo(s):

6-Bromo-N-2-propenyl-4-quinazolinamine

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About This Item

Fórmula empírica (Notação de Hill):
C11H10BrN3
Número CAS:
307538-42-7
Peso molecular:
264.12
Número MDL:
MFCD02166825
Código UNSPSC:
12352200
ID de substância PubChem:
329824598
NACRES:
NA.77

Nível de qualidade

100

Ensaio

>99% (HPLC)

forma

solid

solubilidade

DMSO: >20 mg/mL
H2O: insoluble

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Brc1ccc2ncnc(NCC=C)c2c1

InChI

1S/C11H10BrN3/c1-2-5-13-11-9-6-8(12)3-4-10(9)14-7-15-11/h2-4,6-7H,1,5H2,(H,13,14,15)

chave InChI

BCPOLXUSCUFDGE-UHFFFAOYSA-N

Aplicação

SMER28 may be used in mTOR-mediated signaling studies.

Ações bioquímicas/fisiológicas

SMER28 is a small molecule modulator of mammalian autophagy; enhances A53T alpha-synuclein clearance in PC-12 cells independent of rapamycin treatment; appears to act independent of the mTOR pathway, but combined treatment with saturating rapamycin concentration enhances the effect of either compound alone on A53T alpha-synuclein clearance; autophagy inducers may prove useful in the treatment of neurodegenerative and infectious diseases and cancer.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Dee Shen et al.
Cell biochemistry and biophysics, 60(3), 173-185 (2010-12-07)
Aggresomes and related inclusion bodies appear to serve as storage depots for misfolded and aggregated proteins within cells, which can potentially be degraded by the autophagy pathway. A homogenous fluorescence-based assay was devised to detect aggregated proteins inside aggresomes and
Ann K Rosenthal et al.
The Journal of biological chemistry, 290(21), 13028-13038 (2015-04-15)
Chondrocyte-derived extracellular organelles known as articular cartilage vesicles (ACVs) participate in non-classical protein secretion, intercellular communication, and pathologic calcification. Factors affecting ACV formation and release remain poorly characterized; although in some cell types, the generation of extracellular vesicles is associated
Yu Wu et al.
The FEBS journal, 287(15), 3184-3199 (2020-01-05)
The endo-lysosome system is involved in endocytosis, protein sorting, and degradation as well as autophagy. Numerous toxins and pathogens exploit this system to enter host cells and exert their deleterious effects. Modulation of host endo-lysosome pathway may restrict multiple toxins

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