S5921

Staurosporine

from Streptomyces sp., ≥95% (HPLC), film, protein kinase inhibitor

• Sinônimo(s): Antibiótico AM-2282
• Fórmula empírica (Notação de Hill): C₂₈H₂₆N₄O₃
• Número CAS: 62996-74-1
• Peso molecular: 466.53
• Beilstein: 1060573
• Número MDL: MFCD00077402
• Código UNSPSC: 12161501
• ID de substância PubChem: 24899680
• NACRES: NA.77

Propriedades

• Nome do produto: Estaurosporina, for molecular biology, ≥95% (HPLC)
• grau: for molecular biology
• Nível de qualidade: 300
• Ensaio: ≥95% (HPLC)
• espectro de atividade do antibiótico: fungi
• Modo de ação: enzyme | inhibits
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CN[C@@H]1C[C@@H]2O[C@@](C)([C@@H]1OC)n3c4ccccc4c5c6CNC(=O)c6c7c8ccccc8n2c7c35
• InChI: 1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
• chave InChI: HKSZLNNOFSGOKW-ZGQXJOJZSA-N

Descrição

Descrição geral

Chemical structure: indol derivative

Staurosporine is an alkaloid that is obtained from Streptomyces sp. It possesses a wide range of activities such as protein kinase C inhibitor, inhibition of tumor cell proliferation, and blockage of cell cycle progression in various cells. Staurosporine is a well-known inducer of apoptosis in various cell lines. The mechanisms of staurosporine-induced apoptosis vary among different cell lines that include, mitochondrial apoptotic pathway, Bcl-2 overexpression, and caspase-independent mechanisms. It partially reverses multi-drug resistance (MDR), sensitizing cells with MDR phenotype to cytotoxic agents. Staurosporine inhibits p-glycoprotein (Pgp) phosphorylation. However, the functional significance of Pgp phosphorylation is ill-defined.

Aplicação

Staurosporine has been used as an apoptosis inducer in apoptosis assay in human colorectal cancer cell lines and to evaluate the caspase 3 and 7 activity in endothelial cell line. It has also been used as a positive control in apoptosis assay in human umbilical vein endothelial cells.

Ações bioquímicas/fisiológicas

Inibidor potente da proteína quinase dependente de cálcio/fosfolipídeos. Inibe o aumento da expressão de VEGF em células tumorais.

Características e benefícios

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Nota de análise

Tested for inhibition of interleukin 2 production in Jurkat cells.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H340,H350,H361d,H413
• Declarações de precaução: P202 - P273 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Aquatic Chronic 4 - Carc. 1B - Muta. 1B - Repr. 2
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges