S2947

Anti-Synapsin II (C-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-SYN2, Anti-SYNII, Anti-SYNIIa, Anti-SYNIIb, Anti-Synapsin 2
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• forma: buffered aqueous solution
• peso molecular: antigen ~74 kDa (synapsin IIa)
• reatividade de espécies: human, mouse, rat
• embalagem: antibody small pack of 25 μL
• validação aprimorada: recombinant expression; Learn more about Antibody Enhanced Validation
• concentração: ~1.5 mg/mL
• técnica(s): western blot: 0.25-0/5 μg/mL using extracts of HEK-293T cells expressing human synapsin II, mouse brain extract (S1 fraction), and rat PC12 cell lysate
• nº de adesão UniProt: Q92777
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... SYN2(6854) ; mouse ... Syn2(20965) ; rat ... Syn2(29179)

Descrição

Descrição geral

Synapsins are a family of neuron-specific phosphoproteins that are localized on the cytoplasmic surface of small synaptic vesicles. Synapsins are ubiquitously expressed in neurons. The synapsin 2 (Syn2) gene is located on human chromosome 3p25. It belongs to the neuronal phosphoprotein family.

Especificidade

Anti-Synapsin II(C-terminal) specifically recognizes human, rat and mousesynapsin II.

Imunogênio

synthetic peptide corresponding to amino acids 569-586 of rat synapsin IIa isoform, conjugated to KLH. This sequence is identical in rat synapsin IIa, human synapsin IIa, and mouse synapsin II, and is not found in rat and human synapsin IIb.

Aplicação

Anti-Synapsin II (C-terminal) antibody produced in rabbit may be used in immunoblotting.

Ações bioquímicas/fisiológicas

Synapsins regulate synaptic vesicle clustering and the formation of synaptic terminals. Synapsin II (Syn2) is involved in the formation of synaptic terminals during neuronal development. It can link synaptic vesicles to the actin cytoskeleton, thus regulating the availability of synaptic vesicles for exocytosis. Synapsin II association with synaptic vesicles is controlled by phosphorylation. It is proposed as a candidate associated with increased vulnerability to schizophrenia. It plays an important role in synaptogenesis and neurotransmitter release. Syn2 also helps to locate nitric oxide synthase to the vicinity of its targets.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Armazenamento e estabilidade

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slightturbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)