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S1688

Sigma-Aldrich

SR 57227A

solid

Sinônimo(s):

4-amino-1-(6-chloro-2-pyridyl)-piperidine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C10H14ClN3 · HCl
Número CAS:
77145-61-0
Peso molecular:
248.15
Número MDL:
MFCD01756430
Código UNSPSC:
12352200
ID de substância PubChem:
24278109
NACRES:
NA.77

Formulário

solid

Nível de qualidade

100

cor

white

solubilidade

H2O: soluble 9 mg/mL

cadeia de caracteres SMILES

Cl.NC1CCN(CC1)c2cccc(Cl)n2

InChI

1S/C10H14ClN3.ClH/c11-9-2-1-3-10(13-9)14-6-4-8(12)5-7-14;/h1-3,8H,4-7,12H2;1H

chave InChI

FUMINTAAUJUVMP-UHFFFAOYSA-N

Informações sobre genes

human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)

Aplicação

SR 57227A may be used in 5-HT3-mediated cell signaling studies.

Ações bioquímicas/fisiológicas

Potent and selective 5-HT3 serotonin receptor agonist.
SR 57227A is a highly selective of central and peripheral 5-HT3 receptors and an inhibitor of NMDA receptor-mediated responses in rat cortical pyramidal cells. It exhibits anti-depressant like effects in rats and decreased isolation-induced aggressive behavior.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H315,H319,H335

Classificações de perigo

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
035M4605V
054M4616V
125K46053
125K46052
125K46051

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Visite a Biblioteca de Documentos

Taha Gholipour et al.
Seizure, 19(1), 17-22 (2009-11-28)
There is some evidence that epileptic seizures could be induced or increased by 5-hydroxytryptamine (5-HT) attenuation, while augmentation of serotonin functions within the brain (e.g. by SSRIs) has been reported to be anticonvulsant. This study was performed to determine the
Qiao Jun Zhang et al.
Brain research, 1384, 69-79 (2011-02-05)
In the present study, effect of SR 57227A, a selective 5-hydroxytryptamine-3 (5-HT(3)) receptor agonist, on the firing activity of pyramidal neurons in the medial prefrontal cortex (mPFC) was studied in normal rats and rats with 6-hydroxydopamine lesions of the substantia
M Poncelet et al.
Journal of neural transmission. General section, 102(2), 83-90 (1995-01-01)
We have investigated the effect of SR 57227A, a selective 5-HT3 receptor agonist which crosses the blood brain barrier, on three rodent models in which antidepressants are active. In the forced swimming test, SR 57227A dose-dependently reduced the duration of
Marlies Oostland et al.
The Journal of physiology, 589(Pt 20), 4837-4846 (2011-09-01)
The serotonin 5-HT(3) receptor is the only ligand-gated ion channel activated by serotonin and is expressed by GABAergic interneurons in many brain regions, including the cortex, amygdala and hippocampus. Furthermore, 5-HT(3) receptors are expressed by glutamatergic Cajal-Retzius cells in the
X Liang et al.
Synapse (New York, N.Y.), 29(3), 257-268 (1998-06-23)
The techniques of intracellular recording and single-electrode voltage-clamp were used to study the effect of serotonin (5-HT) and the selective 5-HT3 receptor agonist SR 57227A on N-methyl-D-aspartic acid (NMDA)-evoked responses in pyramidal cells of the rat medial prefrontal cortex (mPFC)
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