RAB0105
Human Cystatin C ELISA Kit
for serum, plasma, cell culture supernatant and urine
Sinônimo(s):
Cystatin-3, Cystatin-C
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About This Item
Código UNSPSC:
41116158
NACRES:
NA.32
Produtos recomendados
reatividade de espécies
human
embalagem
kit of 96 wells (12 strips x 8 wells)
técnica(s)
ELISA: suitable
capture ELISA: suitable
entrada
sample type plasma
sample type urine
sample type serum
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 300 pg/mL
standard curve range: 0.313-20 ng/mL
método de detecção
colorimetric
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... CST3(1471)
Descrição geral
The Human Cystatin C ELISA (enzyme-linked immunosorbent assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human cystatin C in serum, plasma, cell culture supernatants and urine.
Imunogênio
Recombinant Human CystatinC
Aplicação
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Ações bioquímicas/fisiológicas
Cystatin C (CysC) is released by all nucleated cells. Abnormal thyroid function, immunosuppressive therapy and systemic inflammation alter the levels of CysC. Mutation in the gene encoding CysC causes hereditary cystatin C amyloid angiopathy, which is a consequence of amyloid deposits containing the CysC variant in the brain.
Cystatin-C precursor (CST3) is an inhibitor of lysosomal cysteine proteases and several cathepsins like cathepsin S, a lysosomal enzyme. It has been shown that CST3 is a marker of glomerular filtration and diabetic kidney disease. In the presence of pathological conditions, it forms amyloid fibrils in brain arteries. Mutations in the gene encoding CST3 have been shown to be associated with a form of amyloidosis and age-related macular degeneration.
Outras notas
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Met. Corr. 1
Código de classe de armazenamento
8A - Combustible corrosive hazardous materials
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Assessing validity of serum cystatin C for predicting metabolic syndrome.
Asefy Z et.al.
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Critical Care Nephrology, 254-254 (2009)
Handbook of Neurochemistry and Molecular Neurobiology: Neural Protein Metabolism and Function, 254-254 (2009)
Stroke in Icelandic patients with hereditary amyloid angiopathy is related to a mutation in the cystatin C gene, an inhibitor of cysteine proteases.
Levy E et.al.
The Journal of Experimental Medicine, 169(5), 1771-1778 (1989)
The pentapeptide LQVVR plays a pivotal role in human cystatin C fibrillization.
Tsiolaki PL, Hamodrakas SJ, Iconomidou VA.
Febs Letters, 589(1), 159-164 (2015)
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