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R9400

Sigma-Aldrich

Monoclonal Anti-RANTES antibody produced in rat

clone 53405.111, purified immunoglobulin, lyophilized powder

Sinônimo(s):

Anti-D17S136E, Anti-RANTES, Anti-SCYA5, Anti-SIS-delta, Anti-SISd, Anti-TCP228, Anti-eoCP

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About This Item

Número MDL:
MFCD01635727
Código UNSPSC:
51111800
NACRES:
NA.41

fonte biológica

rat

Nível de qualidade

100

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

53405.111, monoclonal

forma

lyophilized powder

purificado por

using protein G

reatividade de espécies

mouse

técnica(s)

immunocytochemistry: 8-25 μg/mL using mouse splenocytes
neutralization: suitable

Isotipo

IgG2a

nº de adesão UniProt

P30882

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

mouse ... Ccl5(20304)

Imunogênio

purified, E. coli-derived, recombinant mouse RANTES.

Ações bioquímicas/fisiológicas

RANTES (Regulated upon Activation, Normal T cell Expressed and Secreted; CCL5) is a chemokine that brings T cells, monocytes, eosinophils, NK cells, dendritic cells and mast cells to the site of infection or inflammation. RANTES has an unusual kinetic profile and is secreted 3-5 days after the activation of the T cells. It also exhibits antimicrobial activity by inducing the production of nitric oxide in macrophages. The expression of RANTES is regulated mainly by JAK/STAT and NF-κB pathways.

forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose pH 7.4.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

13 - Non Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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F Villalta et al.
Infection and immunity, 66(10), 4690-4695 (1998-09-24)
This paper describes a new role for the cysteine-cysteine (CC) chemokines RANTES, MIP-1alpha, and MIP-1beta on human macrophage function, which is the induction of nitric oxide (NO)-mediated trypanocidal activity. In a previous report, we showed that RANTES, MIP-1alpha and MIP-1beta
Alan M Krensky et al.
Nature clinical practice. Nephrology, 3(3), 164-170 (2007-02-27)
Chemokines (chemoattractant cytokines) are fundamental regulators of immune cell movement from the bloodstream into tissues. Regulating expression of chemokines might, therefore, alleviate inflammation in autoimmune diseases and transplant rejection, or augment immune responses in cancer and immunodeficiency. RANTES (regulated upon
V Appay et al.
Trends in immunology, 22(2), 83-87 (2001-04-05)
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some
The unexpected pleiotropic activities of RANTES.
Jay A Levy
Journal of immunology (Baltimore, Md. : 1950), 182(7), 3945-3946 (2009-03-21)
Hye Young Kim et al.
Cytokine, 68(1), 40-49 (2014-03-25)
An anti-inflammatory cytokine, interleukin-10 (IL-10) exerts inhibitory effects on vascular inflammation. Chemokines promote vascular inflammation and play a pathogenic role in the development and maintenance of hypertension. However, chemokine CCL5 has down-regulatory effects on angiotensin II (Ang II)-induced hypertensive mediators.
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