R4408
Chloramphenicol
Ready Made Solution, 100 mg/mL in ethanol: isopropanol (95:5), ≥98% (HPLC)
Sinônimo(s):
D-(-)-threo-2,2-Dichloro-N-[β-hydroxy-α−(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]acetamide
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About This Item
Código UNSPSC:
51102831
NACRES:
NA.85
Produtos recomendados
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
solution
concentração
100 mg/mL in ethanol: isopropanol (95:5)
espectro de atividade do antibiótico
Gram-negative bacteria
Gram-positive bacteria
Modo de ação
protein synthesis | interferes
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
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Aplicação
Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes.
Ações bioquímicas/fisiológicas
Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. It also inhibits mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.
Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.
Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Mode of Resistance: Use of chloramphenicol acetyltransferase will acetylate the product and inactivate it.
Antimicrobial Spectrum: This is a broad spectrum antibiotic against gram-positive and gram-negative bacteria, and is used mainly for ophthalmic and veterinary purposes.
Embalagem
10ml
Nota de preparo
This product is a ready made solution of 100 mg/mL in ethanol:isopropanol (95:5). It is shipped in dry ice and stored at -20°C.
Outras notas
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Storage class (TRGS 510): Flammable liquids")
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Repr. 2
Código de classe de armazenamento
3 - Flammable liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
57.2 °F - closed cup
Ponto de fulgor (°C)
14.0 °C - closed cup
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