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PZ0005

Sigma-Aldrich

Voriconazole

≥98% (HPLC), powder, ergosterol synthesis inhibitor

Sinônimo(s):

2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496

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About This Item

Fórmula empírica (Notação de Hill):
C16H14F3N5O
Número CAS:
137234-62-9
Peso molecular:
349.31
Número MDL:
MFCD00905717
Código UNSPSC:
12352200
ID de substância PubChem:
329823674
NACRES:
NA.77

Nome do produto

Voriconazole, ≥98% (HPLC)

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white

solubilidade

DMSO: >20 mg/mL

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F

InChI

1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1

chave InChI

BCEHBSKCWLPMDN-MGPLVRAMSA-N

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Descrição geral

Voriconazole is a triazole and a synthetic derivative of fluconazole.

Aplicação

Voriconazole has been used:
  • as a control and Erg11 inhibitor in YPD medium
  • as a reference drug to test the activity of essential oils against clinical strains of Candida sp.
  • as an antifungal agent to test its interactions with valproic acid (VPA)
  • to compare its in vitro antifungal activity with essential oils and its components against Cryptococcus neoformans azole-susceptible and not-susceptible clinical isolates

Ações bioquímicas/fisiológicas

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.
Voriconazole is an antifungal, which inhibits ergosterol synthesis.
Voriconazole is used to treat invasive aspergillosis (IA). It is vigorous against Candida species, including the strains of Candida albicans, which shows resistance to fluconazole.

Pictogramas

Skull and crossbonesHealth hazard
GHS06,GHS08

Palavra indicadora

Danger

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral

Órgãos-alvo

Eyes, Liver,Kidney

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
030M4705V
030M7505V
030M47053V
030M47052
030M47051

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Sigma-Aldrich

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Caspofungin diacetate

Isavuconazole ≥98% (HPLC)

Sigma-Aldrich

SML2357

Isavuconazole

Fluconazole-13C3 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

F-035

Fluconazole-13C3 solution

(±)-Voriconazole-D3 solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

V-036

(±)-Voriconazole-D3 solution

Tioconazole 97%

Sigma-Aldrich

03907

Tioconazole

Posaconazole solution 2.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

P-103

Posaconazole solution

Anfotericina B ~80% (HPLC), powder

Sigma-Aldrich

A4888

Anfotericina B

Use of Pinus sylvestris L.(Pinaceae), Origanum vulgare L.(Lamiaceae), and Thymus vulgaris L.(Lamiaceae) essential oils and their main components to enhance itraconazole activity against azole susceptible/not-susceptible Cryptococcus neoformans strains
Scalas D, et al.
BMC Complementary and Alternative Medicine, 18(1), 143-143 (2018)
Identification and evaluation of novel acetolactate synthase inhibitors as antifungal agents
Richie D L, et al.
Antimicrobial agents and chemotherapy, 57(5), 2272-2280 (2013)
pH-dependant antifungal activity of valproic acid against the human fungal pathogen Candida albicans
Chaillot J, et al.
Frontiers in Microbiology, 8, 1956-1956 (2017)
Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study
Whitley M Y, et al.
Annals of Clinical Microbiology and Antimicrobials, 16(1), 60-60 (2017)
Liquid and vapour-phase antifungal activities of essential oils against Candida albicans and non-albicans Candida
Mandras N, et al.
BMC Complementary and Alternative Medicine, 16(1), 330-330 (2016)
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