32483

Voriconazole

VETRANAL^®, analytical standard

• Sinônimo(s): 2R,3S-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol, UK-109496
• Fórmula empírica (Notação de Hill): C₁₆H₁₄F₃N₅O
• Número CAS: 137234-62-9
• Peso molecular: 349.31
• Número MDL: MFCD00905717
• Código UNSPSC: 41116107
• ID de substância PubChem: 329754241
• NACRES: NA.24

Propriedades

• grau: analytical standard
• Nível de qualidade: 100
• linha de produto: VETRANAL^®
• prazo de validade: limited shelf life, expiry date on the label
• técnica(s): HPLC: suitable; gas chromatography (GC): suitable
• aplicação(ões): forensics and toxicology; pharmaceutical (small molecule)
• Formato: neat
• cadeia de caracteres SMILES: C[C@@H](c1ncncc1F)[C@](O)(Cn2cncn2)c3ccc(F)cc3F
• InChI: 1S/C16H14F3N5O/c1-10(15-14(19)5-20-7-22-15)16(25,6-24-9-21-8-23-24)12-3-2-11(17)4-13(12)18/h2-5,7-10,25H,6H2,1H3/t10-,16+/m0/s1
• chave InChI: BCEHBSKCWLPMDN-MGPLVRAMSA-N

Descrição

Descrição geral

Voriconazole is a second-generation triazole, and is derived from fluconazole. It has a broad and enhanced antifungal spectrum as compared to other older triazoles. It is mostly well tolerated and is available in both oral and intravenous formulations.

Aplicação

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Ações bioquímicas/fisiológicas

It has been used as one of the constituent of YPD (1% yeast extract, 2% peptone, 2% glucose) liquid media.

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-α sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Voriconazole is an antifungal used to treat serious fungal infections. Voriconazole inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-a sterol demethylase resulting in a depletion of ergosterol in fungal cell membranes.

Voriconazole is an antifungal, which inhibits ergosterol synthesis.

Informações legais

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06,GHS08
• Palavra indicadora: Danger
• Frases de perigo: H301,H341,H351,H361,H371,H372,H373,H412
• Declarações de precaução: P202 - P260 - P264 - P270 - P273 - P301 + P310
• Classificações de perigo: Acute Tox. 3 Oral - Aquatic Chronic 3 - Carc. 2 - Muta. 2 - Repr. 2 - STOT RE 1 - STOT RE 2 Oral - STOT SE 2 Oral
• Órgãos-alvo: Eyes, Liver,Kidney
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable