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32103

Supelco

Posaconazole

VETRANAL®, analytical standard

Sinônimo(s):

4-[4-[4-[4-[[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

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About This Item

Fórmula empírica (Notação de Hill):
C37H42F2N8O4
Número CAS:
171228-49-2
Peso molecular:
700.78
Número MDL:
MFCD00941162
Código UNSPSC:
41116107
ID de substância PubChem:
329753992
NACRES:
NA.24

grau

analytical standard

Nível de qualidade

100

linha de produto

VETRANAL®

prazo de validade

limited shelf life, expiry date on the label

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

clinical testing

Formato

neat

cadeia de caracteres SMILES

CC[C@@H]([C@H](C)O)N1N=CN(C1=O)c2ccc(cc2)N3CCN(CC3)c4ccc(OC[C@@H]5CO[C@@](C5)(Cn6cncn6)c7ccc(F)cc7F)cc4

InChI

1S/C37H42F2N8O4/c1-3-35(26(2)48)47-36(49)46(25-42-47)31-7-5-29(6-8-31)43-14-16-44(17-15-43)30-9-11-32(12-10-30)50-20-27-19-37(51-21-27,22-45-24-40-23-41-45)33-13-4-28(38)18-34(33)39/h4-13,18,23-27,35,48H,3,14-17,19-22H2,1-2H3/t26-,27+,35-,37-/m0/s1

chave InChI

RAGOYPUPXAKGKH-XAKZXMRKSA-N

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Descrição geral

Posaconazole is an azole antifungal drug used mostly against zygomycetes.

Aplicação

Posaconazole may have been used as reference standard in HPLC analysis for quantification of posaconazole from human plasma.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informações legais

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BCCK0662
BCCH9785
BCCC8920
BCCB7317
BCBT7167

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Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

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Fluconazole ≥98% (HPLC), powder

Sigma-Aldrich

F8929

Fluconazole

Anidulafungin ≥97% (HPLC)

Sigma-Aldrich

SML2288

Anidulafungin

Ravuconazole ≥97% (NMR)

Sigma-Aldrich

SML1216

Ravuconazole

Micafungin sodium ≥97% (HPLC)

Sigma-Aldrich

SML2268

Micafungin sodium

Itraconazole Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1834

Itraconazole

Amphotericin B Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1662

Amphotericin B

vibrant-m

Y0000005

Amphotericin B

Tioconazole 97%

Sigma-Aldrich

03907

Tioconazole

vibrant-m

Y0001361

Amphotericin B for microbiological assay

Florencia Leonardelli et al.
Antimicrobial agents and chemotherapy, 60(9), 5420-5426 (2016-07-07)
Aspergillus fumigatus intrinsic fluconazole resistance has been demonstrated to be linked to the CYP51A gene, although the precise molecular mechanism has not been elucidated yet. Comparisons between A. fumigatus Cyp51Ap and Candida albicans Erg11p sequences showed differences in amino acid
Oliver A Cornely et al.
The Journal of antimicrobial chemotherapy, 72(12), 3406-3413 (2017-09-30)
A two-part (Phase 1B/3), sequential, open-label, multicentre study evaluated the pharmacokinetics (PK) and safety of intravenous (iv) posaconazole given as antifungal prophylaxis to neutropenic patients with AML or myelodysplastic syndrome (MDS) or to recipients at risk of invasive fungal disease
Olga Rivero-Menendez et al.
The Journal of antimicrobial chemotherapy, 74(6), 1586-1590 (2019-03-21)
To investigate the in vitro activity of olorofim (F901318), a novel broad-spectrum antifungal agent, against 150 strains belonging to 16 different cryptic species of Aspergillus by EUCAST and CLSI methodologies. Olorofim, amphotericin B, micafungin, posaconazole and voriconazole were tested against
Shuwen Deng et al.
Emerging microbes & infections, 6(12), e109-e109 (2017-12-07)
This study investigated the triazole phenotype and genotypic of clinical Aspergillus fumigatus isolates from China. We determined the triazole susceptibility profiles of 159 A. fumigatus isolates collected between 2011 and 2015 from four different areas in China tested against 10
Soraya Eugenia Morales-López et al.
Mycopathologia, 181(11-12), 871-878 (2016-09-30)
The presence of the cryptic species belonging to the Candida glabrata complex has not been studied in Argentina. We analyzed a collection of 117 clinical isolates of C. glabrata complex belonging to a National Culture Collection of Instituto Nacional de
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