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03907

Sigma-Aldrich

Tioconazole

97%

Sinônimo(s):

1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole, Thioconazole

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About This Item

Fórmula empírica (Notação de Hill):
C16H13Cl3N2OS
Número CAS:
65899-73-2
Peso molecular:
387.71
Número CE:
265-973-8
Número MDL:
MFCD00057276
Código UNSPSC:
51302325
ID de substância PubChem:
329747834
NACRES:
NA.85

Ensaio

≥96.5% (HPLC)
96.5-103.5% (NT)
97%

forma

powder

cor

white to off-white

espectro de atividade do antibiótico

fungi
yeast

Modo de ação

cell membrane | interferes

cadeia de caracteres SMILES

Clc1ccc(C(Cn2ccnc2)OCc3ccsc3Cl)c(Cl)c1

InChI

1S/C16H13Cl3N2OS/c17-12-1-2-13(14(18)7-12)15(8-21-5-4-20-10-21)22-9-11-3-6-23-16(11)19/h1-7,10,15H,8-9H2

chave InChI

QXHHHPZILQDDPS-UHFFFAOYSA-N

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Descrição geral

Chemical structure: pyrimidine

Aplicação

Tioconazole was used to study the synergistic mechanisms of antifungals on Candida albicans as well as significant drug-drug interactions in vivo.

Ações bioquímicas/fisiológicas

Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by fungus and yeast.It is more active than fluconazole or voriconazole against Candida glabrata mutant strains. It acts by membrane disruption and loss of intracellular ATP.

Embalagem

10G

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Palavra indicadora

Warning

Frases de perigo

H302,H317,H361d,H410

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Wenjiang Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 30(3), 314-318 (2002-02-21)
The interactions of a panel of antifungal agents with cytochromes P450 (P450s), as a means of predicting potential drug-drug interactions, have not yet been investigated. The objective of this study was to evaluate the specificity and selectivity of five antifungal
Synergistic action of nikkomycin X/Z with azole antifungals on Candida albicans.
Slawomir Milewski, Fiorenzo Mignini, et. Al
Microbiology, 137, 2155-2161 (1991)
C Nolting et al.
Mycoses, 40 Suppl 1, 73-75 (1997-01-01)
We report on a 75 year old patient with a bronchial asthma treated at least for 15 years with low dose prednisolone. Under this treatment he developed a tinea follicularis and was demonstrated in our clinic with papulopustular skin lesions
Allergic contact dermatitis from tioconazole.
A Faria et al.
Contact dermatitis, 35(4), 250-252 (1996-10-01)
Karine Bourcier et al.
Drug metabolism and disposition: the biological fate of chemicals, 38(6), 923-929 (2010-03-23)
Imidazoles and triazoles represent major classes of antifungal azole derivatives. With respect to UDP-glucuronosyltransferase (UGT) enzymes, the drug metabolism focus has mainly concentrated on their inhibitory effects with little known about azoles as substrates for UGTs. N-Glucuronide metabolites of the
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