PRS2447

Anti-MTBP antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Sinônimo(s): Anti-Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: rabbit
• conjugado: unconjugated
• forma do anticorpo: affinity isolated antibody
• tipo de produto de anticorpo: primary antibodies
• clone: polyclonal
• Formulário: buffered aqueous solution
• peso molecular: predicted mol wt 104 kDa
• reatividade de espécies: human
• técnica(s): immunocytochemistry: suitable; immunofluorescence: suitable; indirect ELISA: suitable; western blot: suitable
• nº de adesão UniProt: Q96DY7
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... MTBP(27085)

Descrição

Imunogênio

a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids.

Ações bioquímicas/fisiológicas

The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases.

Ligação

The action of this antibody can be blocked using blocking peptide SBP2447.

forma física

Solution in phosphate buffered saline containing 0.02% sodium azide

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable