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Key Documents

PLA0106

Sigma-Aldrich

Rabbit anti-MSH2 Antibody, Affinity Purified

Powered by Bethyl Laboratories, Inc.

Sinônimo(s):

COCA1, FCC1, HNPCC, HNPCC1, LCFS2, MutS protein homolog 2, colon cancer, hMSH2, mutS (E. coli) homolog 2 (colon cancer; nonpolyposis type 1), mutS homolog 2, nonpolyposis type 1, nonpolyposis type 1 (E. coli)

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

Nível de qualidade

100

forma do anticorpo

affinity purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

grau

Powered by Bethyl Laboratories, Inc.

reatividade de espécies

mouse, human

técnica(s)

immunoprecipitation (IP): 2-10 μg/mg
western blot: 1:1,000-1:5,000

nº de adesão

P43246

nº de adesão UniProt

P43246

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

rabbit ... MSH2(4436)

Imunogênio

The epitope recognized by PLA0106 maps to a region between residues 1 and 50 of human mutS homolog 2 using the numbering given in Swiss-Prot entry P43246 (GeneID 4436).

forma física

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% sodium azide

Outras notas

MSH2 is an integral component of the DNA mismatch repair (MMR) system that functions to recognize aberrant structures and signals for the repair of single base mismatches or loops in replicated DNA. MSH2 has also been demonstrated to function as an anti-recombinase and may play a role in negatively regulating DNA repair. MSH2 can heterodimerize with MSH3 or MSH6. Mutations in MSH2 are linked to hereditary nonpolyposis colon cancer (HNPCC).

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Kimberly C Wiegand et al.
Human pathology, 45(6), 1258-1268 (2014-04-29)
ARID1A/BAF250a has been recently implicated as a tumor suppressor in gastric cancer. We sought to clarify the clinical significance of BAF250a/ARID1A in relation to other clinical parameters and relevant biomarkers in gastric carcinoma. Cases from 2 separate cohorts of patients
Raul Alvarado-Bachmann et al.
Molecular medicine reports, 10(2), 1003-1006 (2014-05-27)
Knowledge of the molecular biology of primary colorectal cancer (CRC) has improved in recent years, and one reason for this is the identification of microsatellite instability (MSI), which occurs in up to 15% of sporadic CRC. However, less is known
Anne-Sophie Bats et al.
Anticancer research, 34(6), 3211-3215 (2014-06-13)
To assess the feasibility of Microsatellite Instability (MSI) analysis in uterine cavity washings for detecting endometrial cancer in Lynch syndrome. This was a proof-of-concept study in Lynch syndrome patients, scheduled for hysterectomy. At the beginning of surgical procedure, uterine cavity

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