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Key Documents

P9389

Sigma-Aldrich

Poly(deoxyguanylic-deoxycytidylic) acid sodium salt

double stranded, alternating copolymer

Sinônimo(s):

Poly(dG-dC) • Poly(dG-dC)

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About This Item

Número CAS:
Número MDL:
Código UNSPSC:
41106305
NACRES:
NA.51

fonte biológica

synthetic (organic)

Nível de qualidade

forma

powder or solid

temperatura de armazenamento

−20°C

Descrição geral

Poly(deoxyguanylic-deoxycytidylic) acid (poly(dG-dC)) undergoes salt dependent conformational transition. Under high-salt, it exists as a left-handed double helix and at low-salt it displays B-DNA conformation. However on immobilization, poly(dG-dC) takes up A DNA form.

Aplicação

Poly(deoxyguanylic-deoxycytidylic) acid (Poly(dG-dC) • Poly(dG-dC)) is an alternating copolymer, self-complementary, double-stranded DNA model for conformational studies of DNA structure dynamics and drug interaction.
Poly(deoxyguanylic-deoxycytidylic) acid sodium salt has been used:
  • in electrophoretic mobility shift assay of transcription factor IIIB complex
  • as synthetic copolymers for circular dichroism (CD) spectroscopy studies
  • as a positive control in liquid scintillation counting

Outras notas

Alternating copolymer; self-complementary, form double-stranded complex

Definição da unidade

One unit will yield an A260 of 1.0 in 1.0 ml 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1cm light path).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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