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P4651

Sigma-Aldrich

Promethazine hydrochloride

Sinônimo(s):

10-[2-(Dimethylamino)propyl]phenothiazine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C17H20N2S · HCl
Número CAS:
58-33-3
Peso molecular:
320.88
Beilstein:
4166397
Número CE:
200-375-2
Número MDL:
MFCD00012652
Código UNSPSC:
12352200
ID de substância PubChem:
24277802
NACRES:
NA.77

forma

powder

Nível de qualidade

200

originador

Wyeth

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl[H].CC(CN1c2ccccc2Sc3ccccc13)N(C)C

InChI

1S/C17H20N2S.ClH/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)20-17-11-7-5-9-15(17)19;/h4-11,13H,12H2,1-3H3;1H

chave InChI

XXPDBLUZJRXNNZ-UHFFFAOYSA-N

Informações sobre genes

human ... HRH1(3269)

Procurando produtos similares? Visita Guia de comparação de produtos

Ações bioquímicas/fisiológicas

H1 histamine receptor antagonist; CNS depressant; anticholinergic.

Características e benefícios

This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Outras notas

Solubility: Freely soluble in water, in hot dehydrated alcohol and in Chloroform. Practically insoluble in ether, in acetone and in ethyl acetate.

forma física

Appearance: White or faint yellow, odorless, Crystalline powder, slowly oxidizes and acquires a blue color, on prolonged exposure to air.

Aplicação

Nº do produto
Descrição
Preços

Palavra indicadora

Danger

Frases de perigo

H302,H317,H318,H411

Classificações de perigo

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Sens. 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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A B Wright et al.
Ultrasound in medicine & biology, 25(2), 241-247 (1999-05-13)
This sonographic study was aimed at examining the effect of sedation with promethazine (1.5 mg x kg(-1)), on gastroduodenal function in neonatal piglets. On 3 consecutive days, observations of gastroduodenal motility during the first 3 postprandial h were made in
Z Li et al.
Neuroscience, 70(1), 145-158 (1996-01-01)
Ionic mechanisms responsible for histamine-induced prolonged depolarization in supraoptic nucleus neurons were investigated using whole-cell patch recordings in horizontally prepared brain slices from adult male rats. Bath application of histamine (1-10 microM) in control medium induced membrane depolarization in nine
Frank Fasbender et al.
Archives of toxicology, 94(2), 439-448 (2020-02-16)
Drug-induced liver injury (DILI) represents one of the major causes why drugs have to be withdrawn from the market. In this study, we describe a new interaction between drug-exposed hepatocytes and natural killer (NK) cells. In a previous genome-wide expression
Louis C Leung et al.
Nature, 571(7764), 198-204 (2019-07-12)
Slow-wave sleep and rapid eye movement (or paradoxical) sleep have been found in mammals, birds and lizards, but it is unclear whether these neuronal signatures are found in non-amniotic vertebrates. Here we develop non-invasive fluorescence-based polysomnography for zebrafish, and show-using unbiased, brain-wide
William C Kwan et al.
The Journal of comparative neurology, 527(3), 558-576 (2018-01-03)
The primate visual brain possesses a myriad of pathways, whereby visual information originating at the retina is transmitted to multiple subcortical areas in parallel, before being relayed onto the visual cortex. The dominant retinogeniculostriate pathway has been an area of
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Chromatograms

application for HPLC

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