P246
Monoclonal Anti-PSD95 antibody produced in mouse
clone 7E3-1B8, purified immunoglobulin, buffered aqueous solution
Sinônimo(s):
Anti-MRD62, Anti-PSD95, Anti-SAP-90, Anti-SAP90
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About This Item
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
7E3-1B8, monoclonal
Formulário
buffered aqueous solution
peso molecular
antigen 95 kDa
reatividade de espécies
rat
técnica(s)
immunofluorescence: 1:500
immunoprecipitation (IP): suitable
western blot: 1:2,000
Isotipo
IgG2a
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
rat ... Dlg4(29495)
Descrição geral
DLG4 (discs large MAGUK scaffold protein 4) gene codes for the postsynaptic density-95 (PSD95) protein. Postsynaptic density 95 (PSD-95), a synaptic scaffolding protein is also a membrane-associated guanylate kinase (MAGUK) family protein. It has three PDZ domains on the N terminus followed by a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain. This gene is located on human chromosome 17p13.1.
Especificidade
Reacts with both the recombinant and native rat PSD95. By immunofluorescence with rat hippocampal cells, a staining pattern coincident with NMDA receptor staining at synaptic sites consistent with its proposed role in receptor clustering is observed. Fixation with cold methanol is recommended.
Imunogênio
recombinant rat PSD95 (post synaptic density 95 kDa).
Aplicação
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Immunocytochemistry (1 paper)
Immunofluorescence (1 paper)
Western Blotting (1 paper)
Ações bioquímicas/fisiológicas
Postsynaptic density 95 (PSD-95) plays a major role in bidirectional synaptic plasticity, an important process, essential for learning and memory. It exhibits increased dynamics upon induction of plasticity.
forma física
Solution in phosphate buffered saline containing 0.05% sodium azide.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Capping of the N-terminus of PSD-95 by calmodulin triggers its postsynaptic release
Yonghong Zhang
The Embo Journal (2014)
Human postsynaptic density-95 (PSD95): location of the gene (DLG4) and possible function in nonneural as well as in neural tissues
Stathakis D G, et al.
Genomics, 44(1), 71-82 (1997)
Decreased PSD95 expression in medial prefrontal cortex (mPFC) was associated with cognitive impairment induced by sevoflurane anesthesia* #
Yun-Zhi Ling
Journal of Zhejiang University. Science. B (2015)
Xiao-Mei Liu et al.
The Journal of biological chemistry, 281(25), 17432-17445 (2006-04-21)
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