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P2076

Sigma-Aldrich

Polymyxin B nonapeptide hydrochloride

lyopholized powder

Sinônimo(s):

PMBN

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About This Item

Fórmula empírica (Notação de Hill):
C43H74N14O11 · xHCl
Peso molecular:
963.13 (free base basis)
Número MDL:
MFCD00214217
Código UNSPSC:
12352209
ID de substância PubChem:
24898270
NACRES:
NA.26

Nome do produto

Polymyxin B nonapeptide hydrochloride, cationic cyclic peptide

Nível de qualidade

200

Formulário

lyophilized powder

cor

white to light yellow

aplicação(ões)

cell analysis

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CC(C)CC1NC(=O)C(Cc2ccccc2)NC(=O)C(CCN)NC(=O)C(CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC1=O)C(C)O)NC(=O)C(CCN)NC(=O)C(N)C(C)O

InChI

1S/C43H74N14O11/c1-22(2)20-31-40(65)52-26(10-15-44)35(60)51-29(13-18-47)39(64)57-34(24(4)59)43(68)49-19-14-30(53-36(61)28(12-17-46)54-42(67)33(48)23(3)58)38(63)50-27(11-16-45)37(62)56-32(41(66)55-31)21-25-8-6-5-7-9-25/h5-9,22-24,26-34,58-59H,10-21,44-48H2,1-4H3,(H,49,68)(H,50,63)(H,51,60)(H,52,65)(H,53,61)(H,54,67)(H,55,66)(H,56,62)(H,57,64)

chave InChI

PYHYGIPVYYRJHU-UHFFFAOYSA-N

Categorias relacionadas

Aplicação

Polymyxin B nonapeptide hydrochloride has been used as an outer membrane permeabilizer, to characterize PAßN activity on membrane. It has been used as a control in antibacterial assays.

Ações bioquímicas/fisiológicas

PMBN has endotoxin-neutralizing activity and thus can be utilized in adjunctive therapy against Gram-negative sepsis. It has been found that PMBN is less toxic than polymyxin B. Unlike polymyxin B, PMBN does not exhibit neurotoxicity and nephrotoxicity. While it retains the anti endotoxin property of the parent compound, it is much less potent.
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, specifically increases the permeability of the outer membrane of Gram-negative bacteria toward hydrophobic antibiotics. PMBN has been used to evaluate multidrug efflux inhibitors in E. coli.
Polymyxin B nonapeptide hydrochloride is a derivative of PMB that induces outer membrane permeability in gram-negative bacteria.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
108M4154V
089M4061V
14190309
14180313
018M4136V

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Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents.
Vaara M
Antimicrobial Agents and Chemotherapy, 52(9), 3229-3236 (2008)
Evaluation of multidrug efflux pump inhibitors by a new method using microfluidic channels.
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M Vaara et al.
Antimicrobial agents and chemotherapy, 24(1), 114-122 (1983-07-01)
The outer membrane-disorganizing effect of a short (10-min) treatment with polycationic agents was studied with smooth Salmonella typhimurium used as a test organism. The polycationic agents were the protamine salmine, a lysine polymer with 20 lysine residues (lysine20), and the
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ChemMedChem, 11(22), 2511-2521 (2016-10-19)
With the widespread emergence of drug resistance, there is an urgent need to search for new antimicrobials, especially those against Gram-negative bacteria. Along this line, the identification of viable targets is a critical first step. The protein translocase SecA is
Haim Tsubery et al.
Molecular pharmacology, 62(5), 1036-1042 (2002-10-23)
Polymyxin B nonapeptide (PMBN), a cationic cyclic peptide derived from the antibacterial peptide polymyxin B, is capable of specifically increasing the permeability of the outer membrane (OM) of Gram-negative bacteria toward hydrophobic antibiotics. In this study, we evaluated the contribution
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