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P0500

Sigma-Aldrich

Palmitic acid

≥99%

Sinônimo(s):

1-Pentadecanecarboxylic acid, C16:0, Cetylic acid, Hexadecanoic acid, NSC 5030, PamOH

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About This Item

Fórmula linear:
CH3(CH2)14COOH
Número CAS:
57-10-3
Peso molecular:
256.42
Beilstein:
607489
Número CE:
200-312-9
Número MDL:
MFCD00002747
Código UNSPSC:
12352106
ID de substância PubChem:
24898107
NACRES:
NA.25

pressão de vapor

10 mmHg ( 210 °C)

Nível de qualidade

200

Ensaio

≥99%

Formulário

powder

p.e.

271.5 °C/100 mmHg (lit.)

pf

61-62.5 °C (lit.)

densidade

0.852 g/mL at 25 °C (lit.)

grupo funcional

carboxylic acid

tipo de lipídio

saturated FAs

Condições de expedição

ambient

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CCCCCCCCCCCCCCCC(O)=O

InChI

1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

chave InChI

IPCSVZSSVZVIGE-UHFFFAOYSA-N

Informações sobre genes

human ... FABP2(2169) , FABP3(2170) , FABP4(2167) , FABP5(2171)

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Categorias relacionadas

Descrição geral

Palmitic acid (PA), a saturated fatty acid present in the human body, accounts for 20-30% of total fatty acids (FA) in membrane phospholipids (PL) and adipose triacylglycerols (TAG). It is one of the main components of palm oil however, significant amounts of PA are also found in meat and dairy products, cocoa butter, and olive oil. PA is also present in breast milk. PA performs various fundamental biological functions at cellular and tissue levels.

Aplicação

Palmitic acid has been used:
  • to study its effects on monocyte chemoattractant protein-1 (MCP-1) expression in adipocytes and THP-1 macrophages
  • to stimulate lipotoxicity in primary rat hepatocytes
  • in Et-bovine serum albumin (BSA) solution along with retinoic acid (RA) and retinol to study its effects on spermatogenesis or meiotic progression

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

235.4 °F

Ponto de fulgor (°C)

113 °C

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
SLCJ4649
SLCJ4646
SLCJ1512
SLCJ1511
SLCJ1510

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Palmitoleic acid ≥98.5% (GC), liquid

Sigma-Aldrich

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Palmitoleic acid

Ácido linoleico ≥98%

Sigma-Aldrich

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Ácido linoleico

Jorge Matias Caviglia et al.
Journal of lipid research, 52(9), 1636-1651 (2011-07-02)
Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER
Songtao Li et al.
Biochimica et biophysica acta, 1841(1), 22-33 (2013-09-24)
Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes. Therefore, Nrf2 activation is regarded as an effective strategy against
Chen Shen et al.
Journal of cellular and molecular medicine, 22(7), 3572-3581 (2018-04-20)
Lipotoxicity induced by saturated fatty acids (SFAs) plays a pathological role in the development of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be clearly elucidated. Toll-like receptor (TLR) 4 plays a fundamental role in activating the
Jonas Sieber et al.
The American journal of pathology, 183(3), 735-744 (2013-07-23)
Type 2 diabetes mellitus is characterized by dyslipidemia with elevated free fatty acids (FFAs). Loss of podocytes is a hallmark of diabetic nephropathy, and podocytes are highly susceptible to saturated FFAs but not to protective, monounsaturated FFAs. We report that
B Vessby et al.
Diabetologia, 37(10), 1044-1050 (1994-10-01)
Recent data indicate that peripheral insulin sensitivity may be influenced by dietary fat quality and skeletal muscle phospholipid fatty acid composition. During a health survey of 70-year-old men insulin sensitivity was measured by the euglycaemic hyperinsulinaemic clamp technique and the
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