N7758

Naloxone hydrochloride dihydrate

≥98% (TLC and titration), powder

• Fórmula empírica (Notação de Hill): C₁₉H₂₁NO₄ · HCl · 2H₂O
• Número CAS: 51481-60-8
• Peso molecular: 399.87
• Beilstein: 6260807
• Número MDL: MFCD00150901
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278050
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (TLC and titration)
• forma: powder
• atividade óptica: [α]25/D −178.6°, c = 2.5 in H₂O(lit.)
• cor: white to off-white
• solubilidade: ethanol: 3.3 mg/mL; H₂O: 50 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O.O.Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC=C
• InChI: 1S/C19H21NO4.ClH.2H2O/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;;;/h2-4,14,17,21,23H,1,5-10H2;1H;2*1H2/t14-,17+,18+,19-;;;/m1.../s1
• chave InChI: TXMZWEASFRBVKY-IOQDSZRYSA-N
• Informações sobre genes: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) , OPRS1(10280)

Descrição

Aplicação

Naloxone hydrochloride dihydrate has been used in:

• isotonic saline and injected subcutaneously into experimental rats to study its involvement with withdrawal syndrome in morphine-dependent rats
• as opioid receptor antagonist to examine the role of the endogenous opioid system in infantile amnesia for contextual fear
• as a reference neutral antagonist to define the maximum effect (Emax) of the system

Ações bioquímicas/fisiológicas

Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema.

Características e benefícios

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

Light sensitive.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves