N7537

NSC 663284

≥98% (HPLC), solid

• Sinônimo(s): 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• Fórmula empírica (Notação de Hill): C₁₅H₁₆ClN₃O₃
• Número CAS: 383907-43-5
• Peso molecular: 321.76
• Número MDL: MFCD08276924
• Código UNSPSC: 12352200
• ID de substância PubChem: 24724556
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• condição de armazenamento: protect from light
• cor: red
• solubilidade: DMSO: ≥10 mg/mL; H₂O: insoluble
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• chave InChI: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• Informações sobre genes: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

Descrição

Aplicação

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

Ações bioquímicas/fisiológicas

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): 470.1 °F
• Ponto de fulgor (°C): 243.4 °C
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves