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N1905

Sigma-Aldrich

Neurotrophin-3 human

recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, >97% (SDS-PAGE)

Sinônimo(s):

HDNF, NTF3, NT-3

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About This Item

Número MDL:
MFCD00212404
Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

human

Nível de qualidade

200

recombinante

expressed in baculovirus infected Sf21 cells

Ensaio

>97% (SDS-PAGE)

Formulário

lyophilized powder

potência

1-40 ng/mL EC50

embalagem

pkg of 5 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

nº de adesão UniProt

P20783

temperatura de armazenamento

−20°C

Informações sobre genes

human ... NTF3(4908)

Descrição geral

NTF3 (neurotrophin 3) is a neurotrophic factor belonging to the NGF (nerve growth factor) family. This protein is made up of 257 amino acids, with a prepro region of 138 amino acids and the mature sequence of 119 residues.

Aplicação

Neurotrophin-3 human has been used in the magnetic sorting of oligodendrocyte progenitor cells.

Ações bioquímicas/fisiológicas

Neurotrophin-3 (13.6 kDa or 27.2 kDa dimer) is a member of the neurotrophin family. It has identical amino acid sequence in human, mouse, and pig with full cross-reactivities. NT-3 is important in development and maintenance of neuronal populations and promotes differentiation of neural crest derived sensory and sympathetic neurons. It is critical for proprioceptive 1a afferent neurons, which relay information from peripheral muscle spindles to motoneurons, sending projections to spinocerebellar neurons. NT-3 is also critical in the superior cervical and nodose ganglia.

forma física

Lyophilized from a 0.2 m filtered solution in phosphate buffered saline (PBS) containing 50 μg of bovine serum albumin (BSA) per 1 μg of cytokine.

Nota de análise

The biological activity is measured in a cell proliferation assay using a TrkB-transfected cell line BaF-TrkB-BD.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLBZ1273
SLBX1159
SLBT3032
SLBS0218V
SLBQ6115V

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Neurotrophin-3 modulates breast cancer cells and the microenvironment to promote the growth of breast cancer brain metastasis
Louie E, et al.
Oncogene, 32(35), 4064-4064 (2013)
Defective glial maturation in vanishing white matter disease
Bugiani M, et al.
Journal of Neuropathology and Experimental Neurology, 70(1), 69-82 (2011)
Linkage of the gene for the triple A syndrome to chromosome 12q13 near the type II keratin gene cluster
Weber A, et al.
Human Molecular Genetics, 5(12), 2061-2066 (1996)
Neurotrophin 3 is a mitogen for cultured neural crest cells.
Kalcheim C et al
Proceedings of the National Academy of Sciences of the USA, 89(5), 1661-1665 (1992)
Cloning and expression of a cDNA encoding a novel human neurotrophic factor.
Kaisho Y et al
Febs Letters, 266(1-2), 187-191 (1990)
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Artigos

Derivation of Functional Oligodendrocyte Progenitor Cells (OPCs) from Human Neural Stem Cell Lines

Derivation and characterization of functional human neural stem cell derived oligodendrocyte progenitor cells (OPCs) that efficiently myelinate primary neurons in culture.

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