MAK327
Aldehyde Dehydrogenase Inhibitor Screening Kit
sufficient for 100 colorimetric tests
Sinônimo(s):
ALDH Inhibitor Assay Kit
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Código UNSPSC:
12161503
NACRES:
NA.84
Produtos recomendados
uso
sufficient for 100 colorimetric tests
método de detecção
colorimetric
doença(s) relevante(s)
cancer
temperatura de armazenamento
−20°C
Descrição geral
Aldehyde Dehydrogenases (ALDHs) are a superfamily of oxidoreductases which catalyze the conversion of aldehydes to carboxylic acids. ALDH is crucial in the metabolism of alcohol as alcohol dehydrogenase breaks down ethanol to acetaldehyde. Acetaldehyde, which is toxic to the body, is in turn broken down by ALDH to acetic acid. Imbalances of aldehyde dehydrogenase have been linked to both alcoholism and alcohol sensitivity in people. Inhibitors of the enzyme have been used in cases to treat alcoholism in patients. Cancer stem cell populations also display a heightened activity of ALDH, making ALDH inhibition a promising anti-cancer therapy approach.
Aplicação
The Aldehyde Dehydrogenase Inhibitor Screening Kit may be used for:
- Alcohol Metabolism Research
- Cancer Research
- Drug Discovery
Características e benefícios
- High-Throughput Compatibility: The kit seamlessly integrates into high-throughput handling systems, ensuring efficiency and accuracy.
- Efficient Inhibitor Screening: Screen for ALDH inhibitors with as little as 5 µL of test compound, facilitated by a streamlined procedure requiring minimal effort.
Adequação
Suitable for inhibitor screening and evaluation of ALDH inhibitors.
Princípio
The Aldehyde Dehydrogenase Inhibitor Screening Kit is based on the enzymatic conversion of acetaldehyde to acetic acid and NADH by ALDH. The formed NADH in turn reduces a formazan reagent into a colored product the absorbance of which, measured at 565 nm, is proportional to the enzyme activity in the reaction. The percent inhibition of a test compound can be determined by comparing the activity of ALDH treated with a test compound to the activity of untreated ALDH.
Outras notas
For additional information on our range of Biochemicals, please complete this form.
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 1B
Código de classe de armazenamento
3 - Flammable liquids
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica