M7566
Monoamine Oxidase Insect Cell Control
recombinant, expressed in wild-type baculovirus infected BTI insect cells
Sinônimo(s):
MAO negative control
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About This Item
Produtos recomendados
recombinante
expressed in wild-type baculovirus infected BTI insect cells
Nível de qualidade
forma
liquid
embalagem
vial of ~2.5 mg
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Descrição geral
Monoamine oxidase is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.
Aplicação
Monoamine Oxidase inhibitors (MAOIs) are used to treat mental disorders including depression and Parkinson′s.
This product is suitable as a negative control for MAO-A and MAO-B.
Ações bioquímicas/fisiológicas
Monoamine Oxidase (MAO) is an integral flavoprotein of the outer mitochondrial membrane. MAOs are responsible for catalyzing the oxidative deamination of a wide variety of xenobiotic and endobiotic primary, secondary, and tertiary amines. The primary endogenous function of MAOs involves the inactivation of monoamine neurotransmitters, such as serotonin and dopamine. MAOs exist in two isoforms, MAO-A and MAO-B, which share approximately 70% sequence identity on the amino acid level.1 Both isoforms are nearly ubiquitous in mammals, but show particularly high enzymatic activity in the central nervous system and liver.
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Descrição
Preços
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Certificados de análise (COA)
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Molly Wimbiscus et al.
Cleveland Clinic journal of medicine, 77(12), 859-882 (2010-12-15)
Monoamine oxidase (MAO) inhibitors were the first antidepressants introduced, but their use has dwindled because of their reported side effects, their food and drug interactions, and the introduction of other classes of agents. However, interest in MAO inhibitors is reviving.
M S Benedetti
Fundamental & clinical pharmacology, 15(2), 75-84 (2001-07-27)
Although the cytochrome P450 (CYP) system ranks first in terms of catalytic versatility and the wide range of xenobiotics it detoxifies or activates to reactive intermediates, the contribution of amine oxidases and in particular of monoamine oxidases (MAOs) to the
M B Youdim et al.
Biochemical pharmacology, 41(2), 155-162 (1991-01-15)
Identification, cellular localization, and cDNA cloning of MAO subtypes A and B have increased the insight into the pharmacology of these enzymes, whose primary functions are intra- and extraneuronal inactivation of neurotransmitter (dopamine, noradrenaline and serotonin) and other biogenic amines.
Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors.
A S Kalgutkar et al.
Chemical research in toxicology, 14(9), 1139-1162 (2001-09-18)
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