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Key Documents

M6036

Sigma-Aldrich

Myoglobin from human heart

≥95% (SDS-PAGE), buffered aqueous glycerol solution

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About This Item

Número CAS:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.61

fonte biológica

human heart

Nível de qualidade

Ensaio

≥95% (SDS-PAGE)

forma

buffered aqueous glycerol solution

nº de adesão UniProt

temperatura de armazenamento

−20°C

Informações sobre genes

human ... MB(4151)

Descrição geral

Myoglobin is a heme-related, low-molecular-weight protein. It is mainly found in cardiac and skeletal muscle.

Aplicação

Myoglobin from human heart has been used as a negative control in monitoring isoAsp formation during storage. It has also been used as an antigen in the study to identify self-antigens recognized by serum autoantibodies from unimmunized mice strains.
Myoglobin from human heart was used to study the interactions of a platinum (II) 9-aminoacridine complex with proteins and oligonucleotides by ESI-TOF MS. It was also used in the evaluation of plasma myoglobin using the Stratus CS fluorometer.

Ações bioquímicas/fisiológicas

Myoglobin may help to increase diffusion and also stores O2 in oxidative muscle. It can momentarily act as an oxygen reservoir to supply oxygen when there is inadequate blood oxygen delivery at the time of intense muscular activity.

forma física

Solution in 20 mM Tris-HCl, 1 mM EDTA and 50% glycerol, pH 8.5, 2 mg protein per mL (Lowry)

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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Signe Helbo et al.
PloS one, 9(5), e97012-e97012 (2014-06-01)
The discovery that cysteine (Cys) S-nitrosation of trout myoglobin (Mb) increases heme O2 affinity has revealed a novel allosteric effect that may promote hypoxia-induced nitric oxide (NO) delivery in the trout heart and improve myocardial efficiency. To better understand this
P Couck et al.
Acta clinica Belgica, 60(2), 75-78 (2005-08-09)
Circulating myoglobin is recognized as an early and sensitive marker of acute coronary diseases. Long turnaround time of myoglobin assays jeopardize their clinical utility. We evaluated the analytical performance of the Stratus CS fluorometric enzyme immunoassay based on dendrimer technology
Iron metabolism and its disorders
Clinical biochemistry of domestic animals, 259-285 (2008)
A High-Throughput Bioluminescent Assay to Monitor the Deamidation of Asparagine and Isomerization of Aspartate Residues in Therapeutic Proteins and Antibodies
Hsiao K, et al.
Journal of Pharmaceutical Sciences, 106(6), 1528-1537 (2017)
Oxygen and Carbon Dioxide Transport
Quantitative Human Physiology (2017)

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