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Merck
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Key Documents

M3064

Sigma-Aldrich

Myostatin human

recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinônimo(s):

GDF-8, Growth Differentiation Factor - 8

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About This Item

Número MDL:
MFCD03457656
Código UNSPSC:
12352202
NACRES:
NA.77

fonte biológica

human

Nível de qualidade

200

recombinante

expressed in E. coli

Ensaio

≥95% (SDS-PAGE)

forma

lyophilized powder

peso molecular

16 kDa (including a 31 amino-acid spacer and 6-His tag)

embalagem

pkg of 0.1 mg

técnica(s)

cell culture | mammalian: suitable

nº de adesão UniProt

O14793

temperatura de armazenamento

−20°C

Informações sobre genes

human ... MSTN(2660)

Categorias relacionadas

Aplicação

Use recombinant myostatin to study its mechanisms of action in vitro.

Ações bioquímicas/fisiológicas

Myostatin is a 25 KDa, homodimer, that acts on muscle to induce SMAD family transcription factors such as SMAD2 and SMAD3. It inhibits the differentiation of myoblasts into mature muscle fibers. Positive control for myostatin in Western blots and ELISA.
Positive control for myostatin in Western blots and ELISA.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Karima Relizani et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(8), 1423-1433 (2014-05-28)
Myostatin regulates skeletal muscle size via the activin receptor IIB (ActRIIB). However, its effect on muscle energy metabolism and energy-dependent muscle function remains largely unexplored. This question needs to be solved urgently since various therapies for neuromuscular diseases based on
H Takahashi et al.
Domestic animal endocrinology, 48, 62-68 (2014-06-08)
The purpose of this study was to determine whether myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Plasma concentrations of glucose were lower in DM cattle
Qiang Zhang et al.
The FEBS journal, 277(2), 466-476 (2009-12-18)
The ubiquitin ligase RING finger protein 13 gene (RNF13) was first identified in a screen for genes whose expression is regulated by myostatin in chicken fetal myoblasts. In this study, we demonstrate that the RNF13 gene is broadly expressed in
R E Ferrell et al.
Genomics, 62(2), 203-207 (1999-12-28)
Myostatin is a recently identified member of the transforming growth factor-beta family of regulatory factors, also known as growth and differentiation factor 8 (GDF8). The nucleotide sequence of human myostatin was determined in 40 individuals. The invariant promoter contains a
Yutaka Ohsawa et al.
PloS one, 10(7), e0133713-e0133713 (2015-08-01)
Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating complex. However, which region of the myostatin prodomain is

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