M2547
8-Methoxymethyl-3-isobutyl-1-methylxanthine
≥98%
Sinônimo(s):
8-Methoxymethyl-IBMX
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Fórmula empírica (Notação de Hill):
C12H18N4O3
Número CAS:
Peso molecular:
266.30
Número MDL:
Código UNSPSC:
41106305
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Nível de qualidade
Ensaio
≥98%
Formulário
solid
solubilidade
ethanol: 10 mg/mL
cadeia de caracteres SMILES
O=C1C(N=C(COC)N2)=C2N(CC(C)C)C(N1C)=O
InChI
1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
chave InChI
NBLBCGUCPBXKOV-UHFFFAOYSA-N
Informações sobre genes
human ... PDE1A(5136) , PDE1B(5153)
Ações bioquímicas/fisiológicas
Selective inhibitor of Ca2+-calmodulin-dependent phosphodiesterase I (PDE1).
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Methylxanthine inhibitors of phosphodiesterases.
J N Wells et al.
Methods in enzymology, 159, 489-496 (1988-01-01)
Haruka Kogiso et al.
International journal of molecular sciences, 21(6) (2020-03-18)
In Ts1Rhr, a Down syndrome model mouse, the airway ciliary beatings are impaired; that is, decreases in ciliary beat frequency (CBF) and ciliary bend angle (CBA, an index of ciliary beat amplitude)). A resumption to two copies of the Pcp4
Haruka Kogiso et al.
International journal of molecular sciences, 19(3) (2018-03-03)
Sei-hai-to (TJ-90, Qing Fei Tang), a Chinese traditional medicine, increases ciliary beat frequency (CBF) and ciliary bend angle (CBA) mediated via cAMP (3',5'-cyclic adenosine monophosphate) accumulation modulated by Ca2+-activated phosphodiesterase 1 (PDE1A). A high concentration of TJ-90 (≥40 μg/mL) induced
Wenkuan Xin et al.
American journal of physiology. Renal physiology, 310(10), F994-F999 (2016-02-26)
Large-conductance Ca(2+)-activated K(+) (BK) channels are critical regulators of detrusor smooth muscle (DSM) function. We aimed to investigate phosphodiesterase type 1 (PDE1) interactions with BK channels in human DSM to determine the mechanism by which PDE1 regulates human urinary bladder
H S Ahn et al.
Biochemical pharmacology, 38(19), 3331-3339 (1989-10-01)
In this study three forms of cyclic nucleotide phosphodiesterase (PDE) isolated from rabbit aorta were pharmacologically characterized, and the consequence of selective inhibition of calmodulin-stimulated PDE (CaM-PDE) and cGMP specific PDE (cG-PDE) was evaluated using PDE inhibitors. The cG-PDE (F1)
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica