M168

Methyllycaconitine citrate salt

from Delphinium brownii seeds, ≥96% (HPLC)

• Sinônimo(s): MLA, [1α,4(S),6β,14α,16β]-20-Ethyl-1,6,14,16-tetramethoxy-4-[[[2-(3-methyl-2,5-dioxo-1-pyrrolidinyl)benzoyl]oxy]methyl]aconitane-7,8-diol citrate salt
• Fórmula empírica (Notação de Hill): C₃₇H₅₀N₂O₁₀ · xC₆H₈O₇
• Número CAS: 112825-05-5
• Peso molecular: 682.80 (salt-free basis)
• Número MDL: MFCD00153837
• Código UNSPSC: 12352200
• ID de substância PubChem: 24896681
• NACRES: NA.77

Propriedades

• fonte biológica: Delphinium brownii seeds
• Ensaio: ≥96% (HPLC)
• cor: white
• solubilidade: H₂O: 42 mg/mL
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C(OC[C@]12[C@@]([C@]3([C@H](CC1)OC)[C@@H]4N(C2)CC)([H])[C@@H]([C@]4(O)[C@]5(O)[C@]6([H])[C@@]3([H])C[C@@]([C@H](C5)OC)([H])[C@@H]6OC)OC)C7=CC=CC=C7N8C([C@@H](C)CC8=O)=O.OC(CC(CC(O)=O)(C(O)=O)O)=O
• InChI: 1S/C37H50N2O10.C6H8O7/c1-7-38-17-34(18-49-32(42)20-10-8-9-11-23(20)39-26(40)14-19(2)31(39)41)13-12-25(46-4)36-22-15-21-24(45-3)16-35(43,27(22)28(21)47-5)37(44,33(36)38)30(48-6)29(34)36;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-11,19,21-22,24-25,27-30,33,43-44H,7,12-18H2,1-6H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t19-,21+,22+,24-,25-,27+,28-,29+,30-,33?,34-,35+,36-,37+;/m0./s1
• chave InChI: INBLZNJHDLEWPS-DDIMIZGISA-N

Descrição

Aplicação

Methyllycaconitine citrate salt has been used as an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist:

• to study its effects on inflammatory response in rats post nicotine treatment
• to block the activity of galantamine
• to study its effects on the hepatic branch of the vagus nerve (hVNS) in rats

Ações bioquímicas/fisiológicas

Methyllycaconitine (MLA) is an α7 nicotinic acetylcholine receptor (α7 nAChR) antagonist. It is a norditerpenoid alkaloid synthesized by several species of Delphinium. MLA binds to the binding site of neuronal α-bungarotoxin. Low doses of MLA are associated with improvement of cognition in animals.

Características e benefícios

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)