L6785

Lactacystin

≥90% (HPLC), powder, proteosome inhibitor

• Fórmula empírica (Notação de Hill): C₁₅H₂₄N₂O₇S
• Número CAS: 133343-34-7
• Peso molecular: 376.43
• Número MDL: MFCD01076525
• Código UNSPSC: 12352200
• ID de substância PubChem: 24896445
• NACRES: NA.77

Propriedades

• Nome do produto: Lactacystin, ≥90% (HPLC)
• Nível de qualidade: 200
• Ensaio: ≥90% (HPLC)
• Formulário: powder
• potência: 4 nM K_i (proteasome inhibitor)
• solubilidade: water: 10 mg/mL, clear, colorless
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CC(C)[C@H](O)[C@]1(NC(=O)[C@H](C)[C@@H]1O)C(=O)SC[C@H](NC(C)=O)C(O)=O
• InChI: 1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
• chave InChI: DAQAKHDKYAWHCG-RWTHQLGUSA-N

Descrição

Descrição geral

Lactacystin is an antibiotic and a metabolite of Streptomyces spp.

Aplicação

Lactacystin has been used:

• as a proteasome inhibitor to inhibit protein degradation
• to inhibit proteasomal activity of cells for live cell imaging
• to block proteasomal proteolysis in human monocyte-derived dendritic cells (MoDCs) for 24 h
• to provide unilateral injection to animals to induce nigrostriatal lesions

Ações bioquímicas/fisiológicas

Lactacystin can block the development of cell cycle and stimulate differentiation in a murine neuroblastoma cell line. It can serve as a precursor for clasto-lactacystin β-lactone. Cell-permeable and irreversible proteasome inhibitor (Ki = 4nM). Inhibits NF-kB activation (IC50 = 10mM). Induces neurite outgrowth in neuro2A mouse neuroblastoma cells.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)