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L0649

Sigma-Aldrich

Leupeptin hydrochloride

powder, ≥70% (HPLC)

Sinônimo(s):

Acetyl-Leu-Leu-Arg-al hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C20H38N6O4 · HCl
Número CAS:
24125-16-4
Peso molecular:
463.01
Número MDL:
MFCD00133457
Código UNSPSC:
12352202
ID de substância PubChem:
24896263
NACRES:
NA.77

Nome do produto

Leupeptin hydrochloride, microbial, ≥70% (HPLC)

fonte biológica

microbial

Nível de qualidade

200

Ensaio

≥70% (HPLC)

Formulário

powder

solubilidade

water: 50 mg/mL, clear, colorless to yellow

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H

chave InChI

OQQYPQNFLLAILR-UHFFFAOYSA-N

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Categorias relacionadas

Ações bioquímicas/fisiológicas

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Nota de análise

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
128M4120V
068M4104V
50180608
047M4106V
TEST

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