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I6284

Sigma-Aldrich

Anti-Human IgE (ε-chain specific) antibody produced in goat

affinity isolated antibody, lyophilized powder

Sinônimo(s):

Anti Human Ige, Anti-Human IgE - Anti-Human IgE (ε-chain specific) antibody produced in goat, Anti-Human Ige

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About This Item

Número MDL:
MFCD00162427
Código UNSPSC:
12352203
NACRES:
NA.46

fonte biológica

goat

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

secondary antibodies

clone

polyclonal

Formulário

lyophilized powder

reatividade de espécies

human

técnica(s)

Ouchterlony double diffusion: suitable

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

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Descrição geral

IgE is a class of immunoglobulins that is produced only in mammals. IgE is secreted by mast cells in response to allergens and is important in immunity against parasites. It also is the most important factor in the pathophysiology of anaphylaxis or type I hypersensitivity. The antibody preparation is specific for human IgE when tested against purified human IgA, IgG, IgM, Bence Jones κ, and Bence Jones λ proteins. Identity and purity of the antibody is established by immunoelectrophoresis.

Imunogênio

Purified human IgE (myeloma)

Aplicação

Anti-Human IgE (epsilon-chain specific) antibody may be used as a control in various immunoassays.

forma física

Lyophilized from 0.01 M sodium phosphate, 0.015 M sodium chloride, pH 7.2.

Reconstituição

Reconstitute with 0.135 M sodium chloride to achieve a 1 mg/mL solution of antibody.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
SLCF0672
SLBX4378
SLBN1928V
SLBL1084V
SLBJ0071V

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Shiteng Duan et al.
The Journal of clinical investigation, 129(3), 1387-1401 (2019-01-16)
Allergen immunotherapy for patients with allergies begins with weekly escalating doses of allergen under medical supervision to monitor and treat IgE mast cell-mediated anaphylaxis. There is currently no treatment to safely desensitize mast cells to enable robust allergen immunotherapy with
Bettina Wedi et al.
Allergy, 75(9), 2229-2242 (2020-02-01)
Mas-related G protein-coupled receptor X2 (MRGPRX2) is regarded as a mast cell-specific receptor mediating non-IgE-dependent activation. We aimed to investigate whether human basophils and eosinophils express functional MRGPRX2. Flow cytometry, immunocytochemistry, immunofluorescence, Western blot, and RT-PCR were performed in highly
Stephen J Galli et al.
Nature medicine, 18(5), 693-704 (2012-05-09)
Immunoglobulin E (IgE) antibodies and mast cells have been so convincingly linked to the pathophysiology of anaphylaxis and other acute allergic reactions that it can be difficult to think of them in other contexts. However, a large body of evidence
Jie Zhao et al.
mAbs, 11(5), 837-847 (2019-04-06)
Asthma is characterized by airway hyperresponsiveness and inflammation, as well as underlying structural changes to the airways. Interleukin-4 (IL-4) is a key T-helper type 2 (Th2) cytokine that plays important roles in the pathogenesis of atopic and eosinophilic asthma. We
Minjae Kim et al.
Journal of immunology (Baltimore, Md. : 1950), 208(3), 772-779 (2022-01-14)
Human IgE is useful for immunological assays, such as sensitization of FcεRI-positive cells and IgE measurement. In this study, we report the development of a recombinant Ig fragment, designated IgCw-γεκ, as an alternative reagent to human IgE. IgCw-γεκ (∼130 kDa)

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Anti-Human Antibodies for COVID-19 (SARS-CoV-2) Immunoglobulin Detection Research

Antibody-based serology tests are useful in identifying subjects with an adaptive immune response to the SARS-CoV-2 virus. Anti-human immunoglobulin antibodies allow for quick and simple, yet reliable assays with easy readouts and can also be adapted for high-throughput screening.

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